Results 81 to 90 of about 16,739,290 (349)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A global environmental right [PDF]

, 2013
The development of an international substantive environmental right on a global level has long been a contested issue. To a limited extent environmental rights have developed in a fragmented way through different legal regimes.
Turner, Stephen J.
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Characterization of atypical T cells generated during ex vivo expansion process for T cell-based adoptive immunotherapy

Frontiers in Immunology
Engineered T cell-based adoptive immunotherapies met promising success for the treatment of hematological malignancies. Nevertheless, major hurdles remain to be overcome regarding the management of relapses and the translation to solid tumor settings ...
Patricia Mercier-Letondal, Abhishek Kumar, Chrystel Marton, Francis Bonnefoy, Maxime Fredon, Laura Boullerot, Barbara Dehecq, Olivier Adotévi, Olivier Adotévi, Yann Godet, Jeanne Galaine   +10 more
doaj   +1 more source

Noncommutative generalizations of theorems of Cohen and Kaplansky [PDF]

, 2011
This paper investigates situations where a property of a ring can be tested on a set of "prime right ideals." Generalizing theorems of Cohen and Kaplansky, we show that every right ideal of a ring is finitely generated (resp.
A Kertész, AV Jategaonkar, AV Jategaonkar, AW Goldie, AW Goldie, BL Osofsky, BV Zabavs’kiĭ, D Eisenbud, DV Huynh, EG Evans Jr, G Krause, I Kaplansky, IS Cohen, JA Beachy, JC McConnell, JC Robson, JC Robson, JJ Koker, K Koh, K Koh, KR Goodearl, KR Goodearl, Manuel L. Reyes, ML Reyes, PF Smith, PF Smith, PF Smith, PM Cohn, R Gordon, SA Amitsur, SM Bhatwadekar, TY Lam, TY Lam, TY Lam, TY Lam, TY Lam, TY Lam, VR Chandran, VR Chandran   +38 more
core   +2 more sources

DNA Methylation Analysis: Choosing the Right Method

Biology, 2016
In the burgeoning field of epigenetics, there are several methods available to determine the methylation status of DNA samples. However, choosing the method that is best suited to answering a particular biological question still proves to be a difficult ...
S. Kurdyukov, Martyn Bullock
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Potential Role of the Leucocyte Immunoglobulin-Like Receptors in Kidney Transplant Rejection: A Mini Review

Transplant International
Antibody-mediated rejection (ABMR) remains one of the main causes of long-term graft failure after kidney transplantation, despite the development of powerful immunosuppressive therapy.
Jovanne Palvair, Imane Farhat, Imane Farhat, Mélanie Chaintreuil, Ludivine Dal Zuffo, Lennie Messager, Claire Tinel, Claire Tinel, Baptiste Lamarthée   +8 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source