Results 101 to 110 of about 93,435 (300)

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. [PDF]

, 2014
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
A Babaev, A Bourgoin, A Combes, A Dubin, A Geppert, A Gestel van, A Perel, A Perel, A Rhodes, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, AE Jones, AF Connors Jr, Alexandre Mebazaa, AM Schulman, Andrew Rhodes, AP Wheeler, AS Beraud, B Bouhemad, B Lamia, B Vallet, BP Cholley, BR Soller, C Alberti, C Brun-Buisson, C Brun-Buisson, C Brun-Buisson, C Pierrakos, CA Polanczyk, Christoph Hofer, CI Pro, D Annane, D Atkins, D Backer De, D Backer De, D Backer De, D Backer De, D Backer De, D Fagnoul, D LeDoux, Daniel De Backer, DR Holmes Jr, E Kupersztych-Hagege, E Rivers, E Silva, EP Rivers, F Boissier, F Michard, F Michard, F Vallee, G Friedman, G Hernandez, G Lheritier, G Marecaux, G Tachon, GA Wanner, H Flaatten, H Zhang, H Zhang, HB Nguyen, HH Awad, I Jawad, I Salvo, I Werra de, J Bakker, J Bakker, J Creteur, J Maizel, J Mesquida, Jan Bakker, JB Hall, JD Ricard, Jean Louis Teboul, Jean Louis Vincent, JH McGowan, JJ Ronco, JL Teboul, JL Vanoverschelde, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JP Quenot, JP Revelly, K Bouferrache, L Jacquet, M Antonelli, M Cannesson, M Cecconi, M Cecconi, M Cecconi, M Feissel, M Howell, M Pinsky, MA Hayes, Massimo Antonelli, Maurizio Cecconi, ME Genderen van, ME Genderen van, ME Hands, ME Mikkelsen, MH Weil, MH Weil, MI Monge Garcia, MI Monge Garcia, Michael R. Pinsky, MR Pinsky, MR Shah, NJ Ekbal, O Godje, O Hamzaoui, O Taton, P Asfar, P Asfar, P Vignon, P Wacharasint, PE Marik, PT O’Gara, RA Linton, Richard Beale, RJ Goldberg, RJ Goldberg, Roman Jaeschke, RP Dellinger, RS Hotchkiss, S Harvey, S Heenen, S Magder, S Magder, S Magder, S Magder, S Marque, S Trzeciak, SA Stern, SD Murdoch, SF Nagueh, SG Sakka, SM Cain, SR Ommen, TC Jansen, TC Jansen, TC Jansen, TC Jansen, VS Edul, WH Bickell, WT Linde-Zwirble, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, Y Sakr, Y Sakr   +157 more
core   +5 more sources

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Transient complete heart block following catheter ablation of a left lateral accessory pathway. [PDF]

, 2019
A 16-year-old female with symptomatic Wolff-Parkinson-White (WPW) syndrome underwent catheter ablation of a left-sided lateral accessory pathway. The accessory pathway was eliminated with the first ablation lesion; however, the patient immediately ...
Birgersdotter-Green, Ulrika, Feld, Gregory, Ho, Gordon, Hoffmayer, Kurt, Krummen, David E, Schweis, Franz   +5 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Catheter Interventional Closure of a Large Right Pulmonary Artery-to-Left Atrial Communication in a Neonate [PDF]

, 2018
Right pulmonary artery-to-left atrial communication is a rare congenital vascular malformation that results in a right-to-left shunting. This report describes the case history of a neonate with a large right pulmonary artery-to-left atrial connection ...
Balmer, Christian, Burkamp, Antje, Ghisla, Renzo, Knirsch, Walter, Kretschmar, Oliver   +4 more
core  

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source