Results 51 to 60 of about 1,473,866 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Perioperative management of the vulnerable and failing right ventricle

Perioperative Medicine
Under recognition combined with suboptimal management of right ventricular (RV) dysfunction and failure is associated with significant perioperative morbidity and mortality.
R. C. Arora, J. K. Brown, S. Chatterjee, T. J. Gan, G. Singh, M. Z. Tong, on behalf of the POQI IX Consortium   +6 more
doaj   +1 more source

Catheter‐based embolectomy prior to right ventricular mechanical circulatory support placement after heart transplantation

ESC Heart Failure, 2020
Severe acute isolated right ventricular failure has limited dedicated percutaneous temporary mechanical circulatory support options, especially after orthotopic heart transplantation. The advent of the Impella RP device provides a newer option, though an
Vikrant S. Jagadeesan, Laura J. Davidson, Andrei Churyla, Keith H. Benzuly   +3 more
doaj   +1 more source

Clinical application of risk assessment in PAH: Expert center APRN recommendations

Pulmonary Circulation, 2022
Performing longitudinal and consistent risk assessments for patients with pulmonary arterial hypertension (PAH) is important to help guide treatment decisions to achieve early on and maintain a low‐risk status and improve patient morbidity and mortality.
Melisa Wilson, Jennifer Keeley, Martha Kingman, Susanne McDevitt, Jacqueline Brewer, Frances Rogers, Wendy Hill, Zachary Rideman, Meredith Broderick   +8 more
doaj   +1 more source

Anomalous right pulmonary artery from the aorta [PDF]

, 2006
Anomalous origin of the right pulmonary artery is a rare form of congenital heart disease. It usually presents in early infancy with heart failure and rapid development of pulmonary hypertension. There are about 131 cases reported in the literature and
Mokhtar, S.A.I., Rasool, Aida Hanum Ghulam, Wong, Abdul Rahim   +2 more
core  

Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart [PDF]

, 2010
Right heart function is the main determinant of prognosis in pulmonary arterial hypertension (PAH). At present, no treatments are currently available that directly target the right ventricle, as we will demonstrate in this article.
Allaart, C.P., Handoko, M.L., Man, F.S. de, Paulus, W.J., Vonk Noordegraaf, A., Westerhof, N.   +5 more
core   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children

Children
Pulmonary hypertension (PH) is a progressive disorder characterized by obstructive changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance (PVR), right ventricular (RV) strain, and eventual RV failure (RVF).
Bibhuti B. Das
doaj   +1 more source

Tratamiento de la insuficiencia cardíaca avanzada mediante estimulación biventricular. Experiencia inicial en una serie de 22 casos consecutivos [PDF]

, 2003
Recent data suggest that biventricular pacing may play an important role in treating advanced heart failure in the presence of a significant interventricular and/or intraventricular conduction disorder by correcting cardiac ...
Alegria, E. (Eduardo), Azcarate, P.M. (Pedro María), Barba, J. (Joaquín), Berenguel, A. (Alejandro), Garcia-Bolao, I. (Ignacio), Gavira, J.J. (Juan José), Macias, A. (Alfonso)   +6 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source