Results 61 to 70 of about 1,408,220 (375)

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. [PDF]

, 2019
Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births.
de Soysa, T Yvanka, Del Sol, Antonio, Gifford, Casey A, Huang, Yu, Okawa, Satoshi, Ranade, Sanjeev S, Ravichandran, Srikanth, Salunga, Hazel T, Schricker, Amelia, Srivastava, Deepak   +9 more
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Perioperative management of the vulnerable and failing right ventricle

Perioperative Medicine
Under recognition combined with suboptimal management of right ventricular (RV) dysfunction and failure is associated with significant perioperative morbidity and mortality.
R. C. Arora, J. K. Brown, S. Chatterjee, T. J. Gan, G. Singh, M. Z. Tong, on behalf of the POQI IX Consortium   +6 more
doaj   +1 more source

TRANSPLANTED HEART. RIGHT VENTRICULAR FAILURE, REJECTION OR MYOCARDITIS?

Вестник трансплантологии и искусственных органов, 2011
The differentiation of the cases of the right ventricular failure in transplanted heart should be complex and challenging. The 28-year old man with dilated cardiomyopathy underwent orthotopic heart transplantation.
E. N. Ostroumov, E. D. Kotina, R. Sh. Saitgareev, D. V. Shumakov, E. N. Kazakov, V. N. Poptsov, T. M. Polotskaya, A. Y. Kormer, V. M. Zakharevich, I. M. Ilinsky, N. P. Mojeiko, E. I. Ryaboshtanova, L. V. Beletskaya, A. G. Kupriyanova, R. Y. Voilokova, T. V. Pestretsova, S. V. Mironov, A. E. Ermolenko   +17 more
doaj   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Hepatic and portal vein Dopplers in the clinical management of patients with right-sided heart failure: two case reports

The Ultrasound Journal, 2019
Background Patients with right heart failure pose significant volume management challenges for hemodynamic optimization. We present two cases in which point of care ultrasound (POCUS) of the hepatic and portal veins contributed to the venous hypertension
Matthew Jefkins, Barry Chan
doaj   +1 more source

Tricuspid valve dysplasia in dogs [PDF]

, 2018
A general overview of tricuspid valve dysplasia in dogs is presented in this review. This congenital disease has been described in numerous large dog breeds but especially the Labrador retriever is predisposed.
Bavegems, Valérie, Broeckx, Bart, De Rooster, Hilde, Favril, Sophie, Peelman, Luc, Smets, Pascale   +5 more
core   +1 more source

Normalization of Pulmonary Hypertension by the Use of Left Ventricular Assist Device in Patients with End-stage Heart Failure: A Possible Contribution to Donor Pool Expansion in Lung Transplantation [PDF]

, 2014
SummaryHeart transplantation alone has been recognized to be contraindicated when pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) are irreversible, irrespective of any medical intervention by the use of inotropic agents or ...
Akashi, Hirokazu, Amano, Atsushi, Donna, Mancini, Farr, Maryjane, Hashimura, Kazuhiko, Kato, Tomoko S., Kitakaze, Masafumi, Naka, Yoshifumi, Shahzad, Khurram, Takayama, Hiroo, Yamamoto, Taira   +10 more
core   +2 more sources

Predicting Pulmonary Hypertension by Electrocardiograms Using Machine Learning [PDF]

arXiv, 2023
Pulmonary hypertension (PH) is a condition of high blood pressure that affects the arteries in the lungs and the right side of the heart (Mayo Clinic, 2017). A mean pulmonary artery pressure greater than 25 mmHg is defined as Pulmonary hypertension.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source