Results 51 to 60 of about 4,344,934 (307)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Thoughts about recent education reform in India: Is there a tendency towards privatisation in elementary education? [PDF]

, 2006
The debate in India about the Right to Education Bill 2005 is an example for the basic question in education reform: Is education to be provided by the state or by private actors? With this bill the Government of India (GoI) suggests it\u27s programme to
Holzwarth, Simone
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Realizing human rights in rural Punjab of India: a study of enforcement of selected human rights

Frontiers in Sociology
The realization of human rights assumes great significance in the context of India, the largest democracy in the world. Being a state party to binding international human rights covenants, India is obligated to take measures to ensure the realization of ...
Puneet Pathak, Vagisha Nandini, Deepesh Yadav, Sukhwinder Kaur, Rajinder Kumar Sen, Shanti Riang   +5 more
doaj   +1 more source

The right to education: international aspect [PDF]

, 2017
Актуальність дослідження. Протягом багатьох століть освіта була і  залишається основою розвитку суспільства і  держави. У  ХХ–ХХІ ст. в Україні та більшості країн світу освіта перестала бути привілеєм середнього та вищого класу і є доступною усім ...
Байталюк, Ольга Михайлівна
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hotărârea Curţii Europene a Drepturilor Omului în cauza Flămînzeanu împotriva României [PDF]

Drepturile Omului, 2019
The right to education is not an absolute right, it can be limited by the states by adopting a national law having a legitimate aim, as long as the measures adopted respect the principle of proportionality, are predictable and do not affect the essence ...
Bianca Pătulea
doaj  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The policy gap – research communication in limbo in South Africa's new Green Paper [PDF]

, 2012
South Africa has a shiny new Green Paper on Post-School Education. However policy weary we might be, this is, refreshingly, a good document, with the right ambitions for the overdue overhaul of the higher and further education sector.
Gray, Eve
core  

Citizenship and Education Policies in the post-Yugoslav States [PDF]

, 2012
This paper explores interactions between citizenship and education policies in six post-Yugoslav contexts, focusing on group and individual education rights, ethnocentric, multicultural and civic elements of citizenship in education policies, and the ...
Pantic, Natasa
core   +1 more source