Results 81 to 90 of about 868,065 (299)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2023 El presente trabajo de investigación abarca un tema de suma relevancia en la actualidad como es la criminalización del derecho a la resistencia, el mismo que también se lo considera como una garantía constitucional.
Guano Achig, Tatiana Elizabeth
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Право на сопротивление (восстание): из истории юридического закрепления [PDF]
, 2017 Nemkevich, IV The right to resistance (insurrection): from the history of legal fixationАКТУАЛЬНЫЕ ПРОБЛЕМЫ ТЕОРИИ И ИСТОРИИ ГОСУДАРСТВА И ...
Немкевич, И. В.
core
New Proposals, 2010 Sto:lo fishers maintain that they are the original commercial fishers. However fisheries regulations enacted in 1888 pushed commercial fishing for the Sto:lo to margins outside the law. The Sto:lo continue to fish and engage in the commercial activity
Kimberly Linkous Brown
doaj
BMC Anesthesiology, 2019 Background Increase of pulmonary vascular resistance (PVR) is an efficient method of modulating pulmonary and systemic blood flows (Qp/Qs) for patients with left-to-right (L-R) shunt, and is also closely associated with insufficient oxygen exchange for ...
Peiyi Li, Jun Zeng, Wei Wei, Jing Lin
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Constitutional Right To Resist
Problems of Legality, 2020 The article is devoted to the problem of the constitutional right to resistance. The right to resist is one of the oldest rights, which began its constitutionalization with the appearance of the first constitutional documents - the Declaration of Independence of the United States in 1776, the French Declaration of Human and Civil Rights in 1789 and ...
openaire +5 more sources