Results 101 to 110 of about 1,606,068 (311)

International Laws of War and the African Child: Norms, Compliance, and Sovereignty [PDF]

open access: yes
The Convention on the Rights of the Child of 1989 is one of the most prominent international humanitarian treaty in world history. It entered into force quicker than any other treaty and currently only two countries (the United States and Somalia) have ...
Jeffrey Herbst
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The Child’s Right to Play?!

open access: yesCroatian Journal of Education : Hrvatski časopis za odgoj i obrazovanje, 2014
In this paper the author elaborates the issue of the child's right to play through the UN Convention on the Rights of the Child. As the three main challenges she puts forth the questions of recognition, respect and promotion of children's right to play. Referring to the studies which indicate that the time children spend playing is getting shorter, she
openaire   +4 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

PARENTAL AUTHORITY VERSUS COMMON CUSTODY [PDF]

open access: yesChallenges of the Knowledge Society, 2018
The notion of parental authority introduced to Romanian legislation by the New Romanian Civil Code is totally distinct from the notion of custody specific to other domestic legislations both in theory, as in practical consequences implied.
Anca Magda VOICULESCU
doaj  

Beyond Paternalism: The Role of Counsel for Children in Abuse and Neglect Proceedings [PDF]

open access: yes, 2013
[Excerpt] “Across the nation, lawyers routinely represent children who enter the juvenile court system. Juvenile court systems typically handle two types of cases: delinquency and dependency.
Malempati, Suparna
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Ergenlerin Çocuk Hakları Hakkındaki Görüşlerinin İncelenmesi

open access: yesAnkara Sağlık Bilimleri Dergisi, 2020
Amaç: “Çocuk Hakları” çocukların doğumdan itibaren sahip oldukları; ırk, dil, din, cinsiyet ya da toplumsal farklılıkları kabul etmeden sahip olunan ve çocukların yüksek yararını korumayı amaçlayan haklardır.
Zehra Eriş, Figen Gürsoy, Nur Sena Öz
doaj  

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