Results 61 to 70 of about 193,480 (301)
Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect
Acta Pharmaceutica Sinica B, 2019 Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and ...
Hangyi Wu +10 more
doaj +1 more source
Variational inference of ice shelf rheology with physics-informed machine learning
Journal of Glaciology, 2023 Floating ice shelves that fringe the coast of Antarctica resist the flow of grounded ice into the ocean. One of the key factors governing the amount of flow resistance an ice shelf provides is the rigidity (related to viscosity) of the ice that ...
Bryan Riel, Brent Minchew
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Jixie chuandong, 2013 According to the correlative knowledge of methods mechanics and calculus, the design equations for calculating the bending rigidity and stretching or compressing rigidity about the four kinds of composite flexural hinges are conducted. As an example, the
任宁, 耿铁, 周峰
doaj
Investigation of the fluctuation of the static axial rigidity for double-nut preloaded ball screws
Advances in Mechanical Engineering, 2019 This article aims to investigate the fluctuation of the static rigidity for preloaded ball screws. Based on the correlation between preload and friction torque, a new model to calculate the contact rigidity by friction torque is proposed.
Kai Wang, Chang-guang Zhou, Yi Ou
doaj +1 more source
A very short proof of Forester’s rigidity result [PDF]
Geometry & Topology, 2003 Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol7/paper10.abs ...
openaire +5 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Wage policy and endogenous wage rigidity: a representative view from the inside [PDF]
We report the results from a representative survey of human resource managers in 885 Swedish firms. We estimate that during the severe recession of the 1990s, only 1.1 percent of workers took a cut in regular nominal pay.
Agell, Jonas, Bennmarker, Helge
core +2 more sources
Downward wage rigidity for different workers and firms : an evaluation for Belgium using the IWFP procedure [PDF]
This paper evaluates the extent of downward nominal and real wage rigidity for different categories of workers and firms using the methodology recently developed by the International Wage Flexibility Project (Dickens and Goette, 2006).
Ladislav Wintr +2 more
core +2 more sources