Results 21 to 30 of about 2,147 (178)

A systems biology approach to identify key targets in KRAS/BRAF-mutated colorectal cancer [PDF]

Discover Oncology
Background KRAS and BRAF mutations are critical oncogenic drivers in colorectal cancer (CRC), with distinct molecular and clinical implications. Methods To uncover genes differentially expressed between these mutations, we compared KRAS G12D- and BRAF ...
Shiva Shiravi, Negar Mottaghi-Dastjerdi, Behzad Shahbazi, Nahid Ahmadi, Mohammad Soltany-Rezaee-Rad, Abozar Ghorbani, Hamed Montazeri   +6 more
doaj   +2 more sources

Interleukin-1 Blockade With Rilonacept in Recurrent Pericarditis: Tapering and Discontinuation in Real-World Practice. [PDF]

JACC Adv
Marchetta M, Thomas G, Golino M, Cutts JA, Pan JA, Lopez RI, Clark R, Bigio S, Del Buono MG, Abbate A.   +9 more
europepmc   +2 more sources

Transition to rilonacept monotherapy from oral therapies in patients with recurrent pericarditis [PDF]

, 2022
OBJECTIVE: Polypharmacy management of recurrent pericarditis (RP) often involves long-term therapies, often with negative effects. Slow tapering of oral therapies is often required to avoid recurrence.
Basil S Lewis, Nicholls, Stephen, Martin Lewinter, Antonio Abbate, Paul C Cremer, Liangxing Zou, John F Paolini, Stephen Nicholls, Sushil Allen Luis, Wheeler, Alistair, Alistair Wheeler, Luis, Sushil Allen, Lewis, Basil S, Abbate, Antonio, Paolini, John F, Zou, Liangxing, Insalaco, Antonella, Lewinter, Martin, Klein, Allan L, Antonella Insalaco, Antonio Brucato, Imazio, Massimo, Brucato, Antonio, Lin, David, Massimo Pancrazi, Allan L Klein, Cremer, Paul C, David Lin, Pancrazi, Massimo, Massimo Imazio   +29 more
core   +1 more source

Novel Pathophysiological, Diagnostic and Therapeutic Concepts in Acute and Recurrent Pericarditis

Reviews in Cardiovascular Medicine, 2023
Acute pericarditis is the most frequent pericardial disease characterized by inflammation of the pericardial layers resulting in pain, dyspnea and fatigue.
Aldo Bonaventura, Georgia K Thomas, Michele Golino, Adolfo Gabriele Mauro, Alessandra Vecchié, Marco Giuseppe Del Buono, Stefano Toldo, Nicola Potere, Antonio Abbate   +8 more
doaj   +1 more source

Wirksamkeit und Sicherheit von Rilonacept in der Behandlung von Patientinnen und Patienten mit Kälteurtikaria [PDF]

, 2022
Hintergrund und Zielsetzung Die Kälteurtikaria (KU) charakterisiert sich durch kälteinduzierte, juckende Quaddeln und wird gemäß der aktuellen Leitlinie mit nichtsedierenden Antihistaminika behandelt.
Spittler, Sebastian
core   +1 more source

IL-1 Inhibitors in the Treatment of Monogenic Periodic Fever Syndromes: From the Past to the Future Perspectives

Frontiers in Immunology, 2021
Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders characterized by recurrent episodes of inflammation and a broad range of clinical manifestations.
Hana Malcova, Zuzana Strizova, Tomas Milota, Tomas Milota, Ilja Striz, Anna Sediva, Dita Cebecauerova, Rudolf Horvath, Rudolf Horvath   +8 more
doaj   +1 more source

Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders

Frontiers in Immunology, 2022
BackgroundThe cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be efficacious in treating numerous IL-1-mediated pathologies. Currently, three IL-1
Dennis D. Arnold, Ayla Yalamanoglu, Onur Boyman, Onur Boyman   +3 more
doaj   +1 more source

P154 Rilonacept use in lupus pericarditis

Lupus Science and Medicine
Luigi Adamo, Andrea Fava, Michael Cammarata   +2 more
doaj   +2 more sources

Health-related quality of life in patients with recurrent pericarditis: results from a phase 2 study of rilonacept

BMC Cardiovascular Disorders, 2021
Background Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an exploratory endpoint in a Phase 2 trial evaluating the efficacy and safety of rilonacept (IL-
David Lin, Allan Klein, David Cella, Anna Beutler, Fang Fang, Matt Magestro, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, Antonio Abbate, Andrew Ertel, Leighann Litcher-Kelly, Brittany Klooster, John F. Paolini   +13 more
doaj   +1 more source

Systematic literature review of efficacy/effectiveness and safety of current therapies for the treatment of cryopyrin-associated periodic syndrome, hyperimmunoglobulin D syndrome and tumour necrosis factor receptor-associated periodic syndrome

RMD Open, 2020
Objectives Several therapies are used for the treatment of rareautoinflammatory conditions like cryopyrin-associated periodic fever syndromes (CAPS), hyperimmunoglobulin Dsyndrome (HIDS)/mevalonate kinase deficiency (MKD) and tumour necrosis factor ...
Peter Hur, Syed Raza, Jasmin Beate Kuemmerle-Deschner, Raju Gautam, Aneesh Thomas George, Kathleen Graham Lomax   +5 more
doaj   +1 more source