Results 1 to 10 of about 733,227 (98)

Modulation of adult hippocampal neurogenesis by interleukin 1 signaling [PDF]

Neurobiology of Sleep and Circadian Rhythms
Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders.
Maria I. Smirnova, Ning Quan
doaj   +2 more sources

Evaluation of salivary interleukin 6 interleukin 1 beta and interferon gamma in oral and mucocutaneous lichen planus patients [PDF]

Scientific Reports
Lichen planus (LP) is an immune-mediated disorder affecting mucocutaneous tissues. This study aimed to evaluate and compare the salivary levels of interleukin (IL-6), interleukin-1 beta (IL-1β), and interferon-gamma (IFN-γ) in patients with oral lichen ...
Pardis Nawroz Hama, Khadija Muhamed Ahmed   +1 more
doaj   +2 more sources

Interleukin‐1 Trap Rilonacept Improved Health‐Related Quality of Life and Sleep in Patients With Recurrent Pericarditis: Results From the Phase 3 Clinical Trial RHAPSODY

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Recurrent pericarditis is characterized by painful flares and inflammation, which negatively impact health‐related quality of life. RHAPSODY (rilonacept inhibition of interleukin‐1 alpha and beta for recurrent pericarditis: a pivotal ...
Antonio Brucato, Michelle Z. Lim‐Watson, Allan Klein, Massimo Imazio, David Cella, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, David Lin, Dor Lotan, Massimo Pancrazi, Lucia Trotta, Brittany Klooster, Leighann Litcher‐Kelly, Liangxing Zou, Matt Magestro, Alistair Wheeler, John F. Paolini   +17 more
doaj   +1 more source

Interleukin‐1 pathway in active large vessel vasculitis patients with a poor prognosis: a longitudinal transcriptome analysis

Clinical & Translational Immunology, 2021
Objectives Large vessel vasculitis (LVV) is characterised by a high relapse rate. Because accurate assessment of the LVV disease status can be difficult, an accurate prognostic marker for initial risk stratification is required.
Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Sho Ishigaki, Hiroto Yoshida, Mayu Magi, Yoshihiro Matsumoto, Yuko Kaneko, Tsutomu Takeuchi   +8 more
doaj   +1 more source

Hypothesis: Febrile infection‐related epilepsy syndrome is a microglial NLRP3 inflammasome/IL‐1 axis‐driven autoinflammatory syndrome

Clinical & Translational Immunology, 2021
FIRES (febrile infection‐related epilepsy syndrome) is a protracted neuroinflammatory condition of obscure cause. It mainly afflicts school‐age children and often leads to permanent neurological sequelae.
Wei‐Sheng Lin, Ting‐Rong Hsu
doaj   +1 more source

Revisiting the origin of interleukin 1 in anamniotes and sub-functionalization of interleukin 1 in amniotes

Open Biology, 2022
The cytokine interleukin 1 (IL-1) is an evolutionary innovation of vertebrates. Fish and amphibian have one IL1 gene, while mammals have two copies of IL1, IL1A and IL1B, with distinct expression patterns and differences in their proteolytic activation ...
Eva Hasel de Carvalho, Eva Bartok, Helen Stölting, Baubak Bajoghli, Maria Leptin   +4 more
doaj   +1 more source

Inhibition of interleukin‐1 with rilonacept is not effective in cold urticaria—Results of a randomized, placebo‐controlled study

Clinical and Translational Allergy, 2023
Background Cold urticaria (ColdU) is characterized by pruritic wheals following exposure of the skin to cold. Many patients show insufficient response to antihistamines, the first line treatment.
Hanna Bonnekoh, Monique Butze, Sebastian Spittler, Petra Staubach, Karsten Weller, Jörg Scheffel, Marcus Maurer, Karoline Krause   +7 more
doaj   +1 more source

Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background ST‐segment–elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 blockade with anakinra significantly reduced the area under the curve for hsCRP ...
Antonio Abbate, Cory R. Trankle, Leo F. Buckley, Michael J. Lipinski, Darryn Appleton, Dinesh Kadariya, Justin M. Canada, Salvatore Carbone, Charlotte S. Roberts, Nayef Abouzaki, Ryan Melchior, Sanah Christopher, Jeremy Turlington, George Mueller, James Garnett, Christopher Thomas, Roshanak Markley, George F. Wohlford, Laura Puckett, Horacio Medina de Chazal, Juan G. Chiabrando, Edoardo Bressi, Marco Giuseppe Del Buono, Aaron Schatz, Chau Vo, Dave L. Dixon, Giuseppe G. Biondi‐Zoccai, Michael C. Kontos, Benjamin W. Van Tassell   +28 more
doaj   +1 more source

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Applied Sciences, 2022
Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis ...
José Maria Cardoso, Sofia Duarte, Ana Clara Ribeiro, Paulo Mascarenhas, Susana Noronha, Ricardo Castro Alves   +5 more
doaj   +1 more source

Emerging Therapies for Recurrent Pericarditis: Interleukin‐1 inhibitors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Recurrent pericarditis (RP) is a complex inflammatory disorder associated with adverse outcomes and poor quality of life. After the first episode of acute pericarditis, a non‐negligible group of patients will fail to achieve complete remission despite ...
Saberio Lo Presti, Tarec K. Elajami, Reza Reyaldeen, Chris Anthony, Massimo Imazio, Allan L. Klein   +5 more
doaj   +1 more source