Results 1 to 10 of about 30,614,581 (155)

The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse [PDF]

Mediators of Inflammation, 1992
In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
P. Bjrök, K. Ohlsson
doaj   +5 more sources

Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns

Journal of Neuroinflammation, 2018
Background Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of cardiac arrest.
Mathilde Chevin, Clémence Guiraut, Guillaume Sébire   +2 more
doaj   +2 more sources

Interleukin expression after injury and the effects of interleukin-1 receptor antagonist. [PDF]

PLoS ONE, 2013
Ligament healing follows a series of complex coordinated events involving various cell types, cytokines, as well as other factors, producing a mechanically inferior tissue more scar-like than native tissue.
Connie S Chamberlain, Ellen M Leiferman, Kayt E Frisch, Stacey L Brickson, William L Murphy, Geoffrey S Baer, Ray Vanderby   +6 more
doaj   +1 more source

Interleukin-1 receptors and receptor antagonist in haemodialysis [PDF]

Nephrology Dialysis Transplantation, 1997
Biological activity of interleukin-1 (IL-1) depends on the number and type of IL-1 receptors on target cells and on the amounts of its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1ra).Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic ...
DONATI D., DEGIANNIS D., MAZZOLA E., GASTALDI L., RASKOVA J., RASKA K., CAMUSSI, Giovanni   +6 more
openaire   +3 more sources

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Inflammatory Biomarkers Are Associated With a Decline in Functional Status at Discharge in Children With Acute Respiratory Failure: An Exploratory Analysis

Critical Care Explorations, 2021
OBJECTIVES:. To evaluate the link between early acute respiratory failure and functional morbidity in survivors using the plasma biomarkers interleukin-8, interleukin-1 receptor antagonist, thrombomodulin, and plasminogen activator inhibitor-1.
Erin F. Carlton, MD, MSc, Heidi M. Weeks, PhD, Mary K. Dahmer, PhD, Michael W. Quasney, MD, PhD, Anil Sapru, MD, MAS, Martha A.Q. Curley, PhD, RN, Heidi R. Flori, MD, for the BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Heidi Flori, Michael W. Quasney, Mary K. Dahmer, Anil Sapru, Martha Curley, Michael A. Matthay, Scot T. Bateman, M. D. Berg, Santiago Borasino, G. Kris Bysani, Allison S. Cowl, Cindy Darnell Bowens, E. Vincent S. Faustino, Lori D. Fineman, A. J. Godshall, Ellie Hirshberg, Aileen L. Kirby, Gwenn E. McLaughlin, Shivanand Medar, Phineas P. Oren, James B. Schneider, Adam J. Schwarz, Thomas P. Shanley, Lauren R. Source, Edward J. Truemper, Michele A. Vander Heyden, Kim Wittmayer, Athena Zuppa, David Wypij, Martha A. Q. Curley, David Wypij, Geoffrey L. Allen, Derek C. Angus, Lisa A. Asaro, Judy A. Ascenzi, Scot T. Bateman, Santiago Borasino, Cindy Darnell Bowens, G. Kris Bysani, Ira M. Cheifetz, Allison S. Cowl, Brenda L. Dodson, E. Vincent S. Faustino, Lori D. Fineman, Heidi R. Flori, Linda S. Franck, Rainer G. Gedeit, Mary Jo C. Grant, Andrea L. Harabin, Catherine Haskins-Kiefer, James H. Hertzog, Larissa Hutchins, Aileen L. Kirby, Ruth M. Lebet, Michael A. Matthay, Gwenn E. McLaughlin, JoAnne E. Natale, Phineas P. Oren, Nagendra Polavarapu, James B. Schneider, Adam J. Schwarz, Thomas P. Shanley, Shari Simone, Lewis P. Singer, Lauren R. Source, Edward J. Truemper, Michele A. Vander Heyden, R. Scott Watson, Claire R. Wells   +76 more
doaj   +1 more source

Serum interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels in South Indian fibromyalgia patients and its correlation with disease severity

Indian Journal of Rheumatology, 2021
Background: Fibromyalgia is a chronic pain syndrome characterized by widespread diffuse pain and multiple tender points along with sleep disturbances, fatigue, and psychological distress.
Sandeep Surendran, C B Mithun, Vishnu S Chandran, Suma Balan, Arun Tiwari   +4 more
doaj   +1 more source

Disease Activity Is More Associated with IL-1 Than with IL-6 in Patients with Rheumatoid Arthritis

Life, 2022
Interleukin-1 receptor antagonist (IL-1ra) concentration reflects and is proportional to IL-1 production. Both IL-1 and IL-6 are involved in the pathogenesis of rheumatoid arthritis (RA).
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, María Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra González-Delgado, Miguel Ángel González-Gay, Iván Ferraz-Amaro   +6 more
doaj   +1 more source

Investigation of the Relationship Between IL-1Ra VNTR Variants and Psoriasis

Haseki Tıp Bülteni, 2021
Aim:Psoriasis is an inflammatory skin disease characterized by hyperproliferation of keratinocytes. The imbalance between Interleukin-1 (IL-1)/IL-1 receptor antagonist (IL-1Ra) is associated with increased pro-inflammatory cytokine production and the ...
Aysegul Basak Akadam Teker, Burak Aksan
doaj   +1 more source

Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes. [PDF]

PLoS ONE, 2013
Loss of cardiac myocytes due to apoptosis is a relevant feature of ischemic heart disease. It has been described in infarct and peri-infarct regions of the myocardium in coronary syndromes and in ischemia-linked heart remodeling.
Elena Vecile, Aldo Dobrina, Fadi N Salloum, Benjamin W Van Tassell, Antonella Falcione, Edoardo Gustini, Samuele Secchiero, Sergio Crovella, Gianfranco Sinagra, Nicoletta Finato, Martin J Nicklin, Antonio Abbate   +11 more
doaj   +1 more source