Results 41 to 50 of about 30,614,581 (155)

Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Frontiers in Medicine, 2020
Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes.
Francesca Oliviero, Sara Bindoli, Anna Scanu, Eugen Feist, Andrea Doria, Paola Galozzi, Paolo Sfriso   +6 more
doaj   +1 more source

Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1

Journal of Bone and Mineral Research, 1993
Abstract Recently, the effects of interleukin-1 (IL-1) on bone resorption in organ culture have been shown to be inhibited by an interleukin-1 receptor antagonist (IL-1RA), a novel monocyte cytokine in the IL-1 family. IL-1RA, which binds to IL-1 receptors and inhibits many of the effects of IL-1α and β, has been purified, cloned, and ...
T A, Guise, I R, Garrett, L F, Bonewald, G R, Mundy   +3 more
openaire   +2 more sources

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

The role of Interleukin 1 receptor antagonist in mesenchymal stem cell-based tissue repair and regeneration. [PDF]

, 2020
Interleukin (IL)-1 receptor antagonist (IL-1Ra), a naturally occurring antagonist of IL-1α/IL-1β signaling pathways, has been attributed to the immunosuppressive effects of mesenchymal stem cells (MSCs).
Harrell C., Vladislav Volarevic, Nebojsa Arsenijevic, Markovic, Bojana Simovic, Fellabaum, Crissy, Arsenijevic, Nebojsa, Valentin Djonov, Crissy Fellabaum, Djonov, Valentin, Carl Randall Harrell, Volarevic, Vladislav, Bojana Simovic Markovic, Simovic Markovic, Bojana, Fellabaum C., Harrell, Carl Randall   +14 more
core   +1 more source

A case report of a novel compound heterozygous mutation in a Brazilian patient with deficiency of Interleukin-1 receptor antagonist (DIRA)

Pediatric Rheumatology Online Journal, 2020
Background Deficiency of the natural antagonist of interleukin-1 was first described in 2009 and so far 20 patients has been reported. In Brazil just two cases have been reported both carrying the same homozygous 15 bp deletion.
Leonardo Oliveira Mendonça, Alice Grossi, Francesco Caroli, Robson Aguiar de Oliveira, Jorge Kalil, Fabio Fernandes Morato Castro, Alessandra Pontillo, Isabella Ceccherini, Myrthes Anna Maragna Toledo Barros, Marco Gattorno   +9 more
doaj   +1 more source

Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling

SAGE Open Medical Case Reports, 2014
Chronic tophaceous gout is the end stage of gout. We employed a blockade of interleukin-6 signaling therapy by tocilizumab instead of anakinra, an interleukin-1 receptor antagonist, for a 61-year-old Japanese woman diagnosed with tophaceous gout ...
Sho Mokuda, Masamoto Kanno, Kiyoshi Takasugi, Chikara Okumura, Yuki Ito, Junya Masumoto   +5 more
doaj   +1 more source

Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis. [PDF]

, 2023
Invasive fungal infections are associated with high mortality rates, and the lack of efficient treatment options emphasizes an urgency to identify underlying disease mechanisms.
Joëlle Schläfli, Sabine Muth, Johanna Baumgartner, Carmen Cardozo, Galván, José A, Cem Gabay, Schläfli, Joëlle, Probst, Hans Christian, Graham Martinez, Cristina, Freigang, Stefan, Cristina Graham Martinez, Hans Christian Probst, van Geest, Geert, Grans, Mona, Stefan Freigang, Sabrina Walthert, Geert van Geest, José A. Galván, Gabay, Cem, Rémy Bruggmann, Bruggmann, Rémy, Mona Grans, Baumgartner, Johanna, Cardozo, Carmen, Hang Thi Thuy Gander-Bui, Vera Genitsch, Walthert, Sabrina, Genitsch, Vera, Muth, Sabine, Gander, Thi Thuy Hang   +29 more
core   +2 more sources

GENETIC ASPECTS OF PANNICULITIS IN A RUSSIAN POPULATION: A PILOT STUDY

Научно-практическая ревматология, 2016
Numerous  clinical observations show that the human genetic background plays an important  role in predisposition to many diseases.Objective: to investigate a possible relationship of the polymorphisms in 19 A/G leptin (LEP) gene, in the interleukin (IL)-
M. Yu. Krylov, O. N. Egorova, B. S. Belov   +2 more
doaj   +1 more source

Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors

Cell Communication and Signaling
Background Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer   +8 more
doaj   +1 more source

Peri- and Postoperative Treatment with the Interleukin-1 Receptor Antagonist Anakinra Is Safe in Patients Undergoing Renal Transplantation: Case Series and Review of the Literature

Frontiers in Pharmacology, 2017
In patients undergoing solid organ transplantation, the presence of an interleukin-1 (IL-1) driven disease may require the addition of IL-1 inhibiting drugs to the standard immunosuppressive regimen to protect against inflammation and negative graft ...
Catharina M. Mulders-Manders, Marije C. Baas, Femke M. Molenaar, Anna Simon   +3 more
doaj   +1 more source