Results 61 to 70 of about 30,614,581 (155)

Biologic treatments in rheumatoid arthritis and juvenile idiopathic arthritis [PDF]

, 2006
A number of biological approaches to the management of inflammtory arthropathies have been explored. These include the development of IL-1 receptor antagonists and TNF antagonists. Four biological agents are currently marketed in Europe.
Borg, Andrew A.
core  

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

Journal of Biological Chemistry, 1991
The interleukin-1 receptor antagonist (IL-1ra) inhibits the binding of interleukin-1 (IL-1) to T-cell lines possessing the type I IL-1 receptor; evidence has been published (Carter, D. B., Deibel, M. R. J., Dunn, C. J., Tomich, C. S., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., Harris, P. K. W., Yem, A.
E V, Granowitz, B D, Clark, J, Mancilla, C A, Dinarello   +3 more
openaire   +2 more sources

Radiolabelled GLP-1 receptor antagonist binds to GLP-1 receptor-expressing human tissues. [PDF]

, 2014
PURPOSE Radiolabelled glucagon-like peptide 1 (GLP-1) receptor agonists have recently been shown to successfully image benign insulinomas in patients.
Waser, Beatrice, Reubi, Jean-Claude
core   +2 more sources

A novel mutation of interleukin-1 receptor antagonist (IL1RN) in a DIRA patient from Turkey: Diagnosis and treatment

The Turkish Journal of Pediatrics, 2018
Autoinflammatory diseases can cause severe inflammation in bone and skin such as neonatal-onset multisystem inflammatory disease (NOMID), Majeed syndrome, interleukin-36 receptor antagonist deficiency (DITRA) and deficiency of interleukin-1 (IL-1 ...
Betül Sözeri, Bengü Gerçeker-Türk, Başak Yıldız-Atıkan, Sevgi Mir, Afig Berdeli   +4 more
doaj   +1 more source

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis [PDF]

, 2010
<b>Objective:</b> Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential ...
McInnes, I.B., Lockhart, J.C., Plevin, R., Elizabeth B Kelso, Robin Plevin, Iain B McInnes, Ferrell, W.R., Kelso, E.B., Plevin, R.J., William R Ferrell, John C Lockhart   +10 more
core   +1 more source

MOLECULAR BIOLOGY ANALYSIS OF IL -1Β, IL -4, AND IL -1Β RA GENE POLYMORPHISMS IN ETHNIC BASHKIR PATIENTS WITH RHEUMATOID ARTHRITIS, LIVING IN C HELYABINSK REGION

Медицинская иммунология, 2014
. Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova, D. S. Stashkevich, T. A. Susslova, I. V. Devald, A. O. Issakanova, O. N. Dimcheva   +5 more
doaj   +1 more source

Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist

Communications Biology
Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear.
Paula O. Cooper, Jiang Yang, Hsing-Hui Wang, Meaghan M. Broman, Shyaman Madhawa Jayasundara, Subhransu Sekhar Sahoo, Bingyu Yan, Gada D. Awdalkreem, Gregory M. Cresswell, Liang Wang, Emery Goossens, Nadia A. Lanman, Rebecca W. Doerge, Faye Zheng, Liang Cheng, Saeed Alqahtani, Scott A. Crist, Robert E. Braun, Majid Kazemian, Travis J. Jerde, Timothy L. Ratliff   +20 more
doaj   +1 more source

Cloning and Expression of Recombinant Human Interleukin 1 Receptor Antagonist in Escherichia Coli Strains, BL21 (DE3), Rosetta (DE3), and Origami (DE3)

مجله دانشکده پزشکی اصفهان, 2019
Background: Recombinant human interleukin-1 receptor antagonist (IL-1RA) is a protein with 153 amino acids and molecular weight of 16.83 kDa. This drug protein is known as Anakinra, and has an effective application in the treatment of rheumatoid ...
Hanieh Fardgoli, Seyed Nezameddin Hoseini, Setareh Haghighat   +2 more
doaj   +1 more source

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core   +1 more source

Mitoprotective effect of the receptor antagonist interleukin-1 in experimental cerebral stroke

Patologìâ, 2012
Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats.
E. V. Suprun
doaj   +1 more source