Results 81 to 90 of about 30,614,581 (155)

Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2000
Chronic arthritis is characterised by chronic joint inflammation and concurrent joint erosion and destruction. The inflammatory cytokine interleukin 1 (IL1) has been shown to be a key mediator in the autoimmune disease rheumatoid arthritis (RA). Interleukin 1 mediates bone resorption and cartilage destruction, but may not play as dominant a part in ...
openaire   +2 more sources

Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2–USP5 interactions in the pain pathway

Molecular Pain, 2017
We recently reported that nerve injury or peripheral inflammation triggers an upregulation of the deubiquitinase, USP5 in mouse dorsal root ganglion and spinal dorsal horn. This leads to dysregulated ubiquitination of Cav3.2 T-type calcium channels, thus
Patrick L Stemkowski, Agustin Garcia-Caballero, Vinicius M Gadotti, Said M’Dahoma, Lina Chen, Ivana A Souza, Gerald W Zamponi   +6 more
doaj   +1 more source

In vivo mucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii

BMC Biotechnology, 2003
Background Interleukin-1 (IL-1) is a cytokine involved in the initiation and amplification of the defence response in infectious and inflammatory diseases.
Tagliabue Aldo, Medaglini Donata, Xu Li, Bossù Paola, Maggi Tiziana, Ruggiero Paolo, Macchia Giovanni, Ricci Susanna, Hammarström Lennart, Pozzi Gianni, Boraschi Diana   +10 more
doaj   +1 more source

Interleukin-1 receptor antagonist, interleukin-2 receptor alpha subunit and amyotrophic lateral sclerosis.

, 2020
BACKGROUND AND PURPOSE: To clarify the causal associations of interleukin-1 receptor antagonist (IL-1ra) and interleukin-2 receptor alpha subunit (IL-2rα) with the risk of amyotrophic lateral sclerosis (ALS). METHODS: A two-sample Mendelian randomization
Roos, P M, Larsson, SC, Roos, PM, Yuan, S,, Yuan, S, Larsson, Susanna C., Larsson, Susanna C.,   +6 more
core   +1 more source

Deficiency of interleukin-1 receptor antagonist: A systematic review

The Turkish Journal of Gastroenterology
Objectives: The study aimed to conduct a systematic literature review of the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of patients with deficiency of the interleukin-1 receptor antagonist (DIRA) and determine the ...
Wérgila Ruana Gonçalves Barros, Jucier Gonçalves Júnior   +1 more
doaj  

NOCICEPTIN/ORPHANIN FQ RECEPTOR LIGANDS: PHARMACOLOGICAL STUDIES [PDF]

, 2009
The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. At cellular level N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents.
Fischetti, Carmela, Carmela Fischetti (7591079)   +1 more
core  

Solution structure of human interleukin-1 receptor antagonist protein [PDF]

, 1994
Interleukin-1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin-1 receptor. In contrast to IL-1β IRAP binds to the IL-1 receptor but does not elicit a physiological response.
Stockman, Brian J., Strakalaitis, Nancy A., Deibel, Martin R., Anthony W. Yem, Martin R. Deibel, Brunner, David P., Terrence A. Scahill, Nancy A. Strakalaitis, Yem, Anthony W., David P. Brunner, Scahill, Terrence A., Brian J. Stockman   +11 more
core   +1 more source

Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B., Robertson, S.E., Gracie, J.A.   +2 more
core   +1 more source

Partial response to anakinra in life-threatening Henoch-Schönlein purpura: case report

Pediatric Rheumatology Online Journal, 2011
Henoch-Schönlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening ...
Boyer Erynn M, Turman Martin, O'Neil Kathleen M   +2 more
doaj   +1 more source

An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta.

, 1991
The cytokine interleukin-1 beta may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus.
Eizirik, Decio L., Sandler, S, Tracey, D E, Bendtzen, K   +3 more
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