Results 101 to 110 of about 30,614,581 (155)

Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance

Swiss Medical Weekly, 2008
O Osborn, H Gram, EP Zorrilla, B Conti, T Bartfai   +4 more
doaj   +1 more source

Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist

JAAD Case Reports
Nathan Mooney, MMSc, Arshpreet Grewal, BS, Susan Pei, MD, Paul Bogner, MD, Drew Kuraitis, MD, PhD   +4 more
doaj   +1 more source

Interleukin-1 receptor antagonist: effectiveness against interleokin-1 fever

Canadian Journal of Physiology and Pharmacology, 1992
Conscious cats were used to examine the effectiveness of the interleukin-1 receptor antagonist against the fever induced by interleukin-1 and endotoxin. Although inactive by itself, the antagonist (three 1-μg bolus injections at 10-min intervals), injected into the third ventricle, attenuated the febrile response to a subsequent ...
COCEANI, Flavio, LEES J, REDFORD J, BISHAI I.   +3 more
openaire   +4 more sources

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Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction

Atherosclerosis, 2009
The overall effect of the major pro-inflammatory cytokine interleukin-1 (IL-1) on coagulation and fibrinolysis is prothrombotic. We recently found that haplotype 5 (H5) of the gene (IL1RN) coding for the interleukin-1 receptor antagonist (IL-1Ra), the natural inhibitor of IL-1, is associated with an increased risk of venous thrombosis.
Stephanie Bezzina Wettinger, Cjm Doggen
exaly   +3 more sources

Co-localization of interleukin-1 receptor type I and interleukin-1 receptor antagonist with vasopressin in magnocellular neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus

Neuroscience, 1999
Interleukin-1 receptor type I and interleukin-1 receptor antagonist were found in magnocellular neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus by immunohistochemical detection. Double-labelling experiments revealed that both
Marianne Schultzberg, A -M van Dam, A M van Dam   +2 more
exaly   +2 more sources

INTERLEUKIN-1 RECEPTOR ANTAGONIST

Rheumatic Disease Clinics of North America, 1998
There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells.
B, Bresnihan, G, Cunnane
openaire   +2 more sources

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
openaire   +3 more sources

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

International Reviews of Immunology, 1998
IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
openaire   +2 more sources

INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

Annual Review of Immunology, 1998
▪ Abstract  The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form ...
W P, Arend, M, Malyak, C J, Guthridge, C, Gabay   +3 more
openaire   +2 more sources

Interleukin-1 Receptor Antagonist Expression in Sarcoidosis

American Review of Respiratory Disease, 1993
Abstract Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant cells, and variable degrees of fibrosis.
M W, Rolfe, T J, Standiford, S L, Kunkel, M D, Burdick, A R, Gilbert, J P, Lynch, R M, Strieter   +6 more
openaire   +2 more sources