Results 111 to 120 of about 30,614,581 (155)
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Interleukin‐1 receptor antagonist in the fetomaternal compartment
Acta Paediatrica, 1995Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
K, Bry +4 more
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Nature, 1990Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
C H, Hannum +9 more
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Interleukin-1 Receptor Antagonist
1993IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
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Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer
Gynecologic Oncology, 1991The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
L, Van Le +3 more
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Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.
Alimentary Pharmacology & Therapeutics, 1996Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
F, Cominelli, T T, Pizarro
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Journal of Endocrinology, 1997
Abstract Interleukin-1 (IL-1) is a multifunctional cytokine with profound effects on ovarian function. The effects of IL-1 on ovarian steroidogenesis have been demonstrated in several species. IL-1 mRNA levels are increased in the thecal layer of the ovulating follicle and IL-1β has been shown to induce ovulations in vitro.
Wang, L. +6 more
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Abstract Interleukin-1 (IL-1) is a multifunctional cytokine with profound effects on ovarian function. The effects of IL-1 on ovarian steroidogenesis have been demonstrated in several species. IL-1 mRNA levels are increased in the thecal layer of the ovulating follicle and IL-1β has been shown to induce ovulations in vitro.
Wang, L. +6 more
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Interleukin-1 receptor antagonist
2000Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruction, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
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Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus
Immunological Investigations, 1997Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
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Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis
Arthritis & Rheumatism, 1994AbstractObjective. To quantify interleukin‐1 receptor antagonist (IL‐1ra) and IL‐1 production and gene expression by rheumatoid arthritis (RA) synovial tissue (ST) cells.Methods. IL‐1α, IL‐1β, and IL‐1ra protein levels were measured by enzyme‐linked immunosorbent assay in fresh and cultured ST cells, purified synovial macrophages, and fibroblast‐like ...
G S, Firestein +6 more
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Interleukin-1 and interleukin-1 receptor antagonist.
Nutrition (Burbank, Los Angeles County, Calif.), 1996Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
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