Results 21 to 30 of about 30,614,581 (155)

Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer

Frontiers in Pharmacology, 2017
Background: Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies.
Nicole Armbruster, Nicole Armbruster, Jennifer Krieg, Jennifer Krieg, Manuel Weißenberger, Carsten Scheller, Andre F. Steinert   +6 more
doaj   +1 more source

Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression

Biomedicines, 2020
Background: Inflammation is known to promote tumor formation and progression; however, we found a natural anti-inflammatory factor, interleukin (IL)-1 receptor antagonist (IL1RN), in a mouse transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1 ...
Yu-Ching Fan, Kuan-Der Lee, Yuan-Chin Tsai   +2 more
doaj   +1 more source

Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist

Communications Biology, 2021
Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention ...
Jean L. Tan, Blake Lash, Rezvan Karami, Bhavana Nayer, Yen-Zhen Lu, Celeste Piotto, Ziad Julier, Mikaël M. Martino   +7 more
doaj   +1 more source

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Pfeilschifter, Josef, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Koehl, Ulricke, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +40 more
core   +1 more source

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.), Rehart, Stefan, Kalina, Uwe, Kessler, Uta, Kukoc-Zivojnov, Natasa, Kaltwasser, Joachim Peter (Prof. Dr.), Ottmann, Oliver G., Möller, Burkhard   +7 more
core   +1 more source

Studying the Pharmacokinetics of Interleukin-1RA Mutants

Bioscientific Review, 2019
The two antagonists for interleukin-1 (IL-1) system are IL-1α, and IL-1β. IL-1 receptor antagonist (IL-1RA) is another naturally occurring non-competitive antagonist. All three antagonists are bound to two receptors that are IL-R1 and IL-1R2.
Iqra Khuzaima, Kanwal Iftikhar, Uroosa Tabarruk, Haleema Sadia, Khadija Shami   +4 more
doaj   +1 more source

Apolipoprotein B and interleukin 1 receptor antagonist: reversing the risk of coronary heart disease

Frontiers in Endocrinology, 2023
AimsEpidemiological evidence for the link of interleukin 1 (IL-1) and its inhibition with cardiovascular diseases (CVDs) remains controversial. We aim to investigate the cardiovascular effects of IL-1 receptor antagonist (IL-1Ra) and underlying ...
Fangkun Yang, Fangkun Yang, Fangkun Yang, Ning Huangfu, Ning Huangfu, Ning Huangfu, Jiaxi Shen, Jiaxi Shen, Pengpeng Su, Lujie Zhu, Lujie Zhu, Hanbin Cui, Hanbin Cui, Hanbin Cui, Shuai Yuan   +14 more
doaj   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A., Mashhadi, Farzaneh Farajian, Naylor, Robert J.   +2 more
core   +5 more sources

Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1β and IL-1ra production in multiple sclerosis

Mediators of Inflammation, 2003
Background: Multiple sclerosis (MS) is an autoimmune disorder, with a considerable genetic influence on susceptibility and disease course. Cytokines play an important role in MS pathophysiology, and genes encoding various cytokines are logical candidates
Hans M. Schrijver, Jaco van As, J. Bart A. Crusius, Christien D. Dijkstra, Bernard M. J. Uitdehaag   +4 more
doaj   +1 more source

Opium addiction increases interleukin 1 receptor antagonist (IL-1Ra) in the coronary artery disease patients. [PDF]

PLoS ONE, 2012
BACKGROUND: There is evidence that opium addiction has immunosuppressant effects. Coronary artery disease (CAD) is a condition resulted from atherosclerosis which is dependent on the immune response.
Habibollah Saadat, Seyed Ali Ziai, Maryam Ghanemnia, Mohammad Hasan Namazi, Morteza Safi, Hosein Vakili, Ali Dabbagh, Omid Gholami   +7 more
doaj   +1 more source