Results 51 to 60 of about 2,147 (178)
Schnitzler syndrome, a rare autoinflammatory disease. Complete response to IL-1 blockade
Clinics and Practice, 2017 The Schnitzler syndrome (SCS) is a rare, late-onset acquired autoinflammatory syndrome often underdiagnosed. The diagnosis is based on the Lipsker and recently on validated Strasbourg diagnostic criteria (chronic urticarial rash, monoclonal gammopathy ...
Paola Faggioli +3 more
doaj +1 more source
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Adult‐onset Still's disease (AOSD) is a rare, multisystem autoinflammatory disorder characterized by a classic triad of fever, evanescent rash, and arthritis with diagnostic challenges. We present a case of a previously healthy 22‐year‐old Nepalese female presented with a 1.5‐month history of progressive bilateral lower limb edema and a 13‐day
Sushil Silwal +3 more
wiley +1 more source
Frontiers in Immunology, 2022 Newly emerging variants of coronavirus 2 (SARS-CoV-2) raise concerns about the spread of the disease, and with the rising case numbers, the Coronavirus disease 2019 (COVID-19) remains a challenging medical emergency towards the end of the year 2021 ...
Pamir Atagündüz +2 more
doaj +1 more source
Case Reports in Immunology, Volume 2026, Issue 1, 2026.Drug‐induced hypereosinophilic syndromes (HESs) have been associated with a variety of medications, including biologic agents. We present a case of an 85‐year‐old female with a history of giant cell arteritis (GCA) complicated by ascending aortic aneurysm and aortitis, who developed marked peripheral eosinophilia (peaking at 3710/µL) and a persistent ...
Mani Maheshwari +4 more
wiley +1 more source
Review of Biological Agents in the Therapeutic Management of Monogenic Genodermatoses
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Monogenic genodermatoses encompass a diverse group of over 400 distinct disorders, presenting significant therapeutic challenges. Recent advancements in the clinical application of biological agents have heralded a new era in the management of these conditions.
Xueying Wang +4 more
wiley +1 more source
IL-1 inhibition in systemic juvenile idiopathic arthritis
Frontiers in Pharmacology, 2016 Systemic juvenile idiopathic arthritis (sJIA) is the form of childhood arthritis whose treatment is most challenging. The demonstration of the prominent involvement of interleukin (IL)-1 in disease pathogenesis has provided the rationale for the ...
Gabriella Giancane +5 more
doaj +1 more source
Evaluation of the Effect of IL‐1 Antagonists on Pituitary Function
International Journal of Endocrinology, Volume 2026, Issue 1, 2026.Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease frequently observed in populations along the Eastern Mediterranean coast, characterized by recurrent fever, abdominal pain, and joint inflammation. The disease results from mutations in the MEFV gene, which plays a critical role in regulating IL‐1β secretion ...
Fadime Aktas Koc +3 more
wiley +1 more source
Targeted Anti‐Inflammatory Therapy in Cardiovascular Events: Challenges and Opportunities
The Journal of Clinical Hypertension, Volume 27, Issue 11, November 2025.ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Emerging evidence suggests that inflammation plays a pivotal role in the pathogenesis of atherosclerosis and subsequent cardiovascular events. Traditional treatments primarily focus on lipid‐lowering and antithrombotic strategies; however, these ...
Li Feng +3 more
wiley +1 more source
The Egyptian Journal of Internal Medicine, 2014 Gout is a crystal deposition disease caused by raised levels of uric acid in the blood (hyperuricaemia) with persistence of hyperuricemia at levels higher than a serum saturation of 6.8 mg/dl leads to formation of monosodium urate (MSU) crystals and ...
Hanan Abdel Rehim
doaj +1 more source