Results 81 to 90 of about 2,147 (178)

Interleukin-1 (IL-1) inhibitors : anakinra, rilonacept, and canakinumab

, 2016
Inhibitors of interleukin-1 (IL-1) are proteins which decrease the actions of the inflammatory cytokine, IL-1. There are two general mechanisms of IL-1 inhibitors: binding to the IL-1 receptor (anakinra) or binding directly to IL-1 (rilonacept and ...
Mahler, Stephen M., Pile, Kevin (R17082), Stephen M. Mahler, Garry G. Graham, Kevin D. Pile, Graham, Garry G.   +5 more
core   +1 more source

Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives

Journal of Functional Biomaterials
This review aimed at searching literature for data regarding the inflammasomes’ involvement in the pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms ...
Norina Vinţeler, Claudia Nicoleta Feurdean, Regina Petkes, Reka Barabas, Bianca Adina Boşca, Alexandrina Muntean, Dana Feștilă, Aranka Ilea   +7 more
doaj   +1 more source

Algorithm development for corticosteroid management in systemic juvenile idiopathic arthritis trial using consensus methodology

Pediatric Rheumatology Online Journal, 2012
Background The management of background corticosteroid therapy in rheumatology clinical trials poses a major challenge. We describe the consensus methodology used to design an algorithm to standardize changes in corticosteroid dosing during the ...
Ilowite Norman T, Sandborg Christy I, Feldman Brian M, Grom Alexi, Schanberg Laura E, Giannini Edward H, Wallace Carol A, Schneider Rayfel, Kenney Kathleen, Gottlieb Beth, Hashkes Philip J, Imundo Lisa, Kimura Yukiko, Lang Bianca, Miller Michael, Milojevic Diana, O’Neil Kathleen M, Punaro Marilynn, Ruth Natasha, Singer Nora G, Vehe Richard K, Verbsky James, Woodward Amy, Zemel Lawrence   +23 more
doaj   +1 more source

Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis: a systematic review and meta-analysis of randomized trials [PDF]

, 2016
ObjectiveTo define the optimal biologic agent for systemic JIA (sJIA) based on safety and efficacy data from a randomized controlled trial (RCT).MethodsThrough a systematic literature search, sJIA RCTs evaluating biologic agents were identified.
Christensen, Robin, Furst, Daniel E, Pope, Tracy D, Woo, Jennifer MP, Tarp, Simon, Amarilyo, Gil, Cohen, Neta, Foeldvari, Ivan   +7 more
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Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome

Open Access Rheumatology: Research and Reviews, 2011
Pierre QuartierUnité d'Immunologie-Hématologie et Rhumatologie pédiatriques, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, FranceAbstract: Cryopyrin-associated ...
Pierre Quartier
doaj  

Cryopyrin-Associated Periodic Syndromes (CAPS): Pathogenesis, Clinical Manifestations, and IL-1-Targeted Therapeutic Strategies

Journal of Education, Health and Sport
Cryopyrin-associated periodic syndromes (CAPS) are a group of rare, genetically determined autoinflammatory diseases resulting from gain-of-function mutations in the NLRP3 gene.
Joanna Nadaj, Bartosz Czyżewski, Anna Mariankowska, Anna Dróżdż, Weronika Posuniak, Michał Dorota, Karol Kozłowski, Oliwia Kawa, Wojciech Żywiec, Cezary Milczarek   +9 more
doaj   +1 more source

Cardiac magnetic resonance imaging paralleled recurrent pericarditis clinical response to rilonacept treatment over 18 months: a RHAPSODY subgroup analysis [PDF]

Cardiac magnetic resonance imaging paralleled recurrent pericarditis clinical response to rilonacept treatment over 18 months: a RHAPSODY subgroup analysis Authors: Paul C.
Curtis, Allison, RHAPSODY Investigators, Insalaco, Antonio, Paolini, John F., Klein, Allan L., Imazio, Massimo, Brucato, Antonio, Jellis, Christine L., Kwon, Deborah H., Cremer, Paul C., Luis, Sushil A., Lin, David, Clair, JoAnn, Wang, Sheldon   +13 more
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Interleukin inhibitors and the associated risk of candidiasis

Frontiers in Immunology
Interleukins (ILs) are vital in regulating the immune system, enabling to combat fungal diseases like candidiasis effectively. Their inhibition may cause enhanced susceptibility to infection.
Sabir Khan, Hazrat Bilal, Muhammad Nadeem Khan, Wenjie Fang, Wenqiang Chang, Bin Yin, Ning-jing Song, Zhongrong Liu, Dongxing Zhang, Dongxing Zhang, Fen Yao, Xun Wang, Qian Wang, Lin Cai, Bing Hou, Jiayue Wang, Chunyan Mao, Lingxi Liu, Yuebin Zeng, Yuebin Zeng   +19 more
doaj   +1 more source

The role of the NLRP3 inflammasome in gout

Journal of Inflammation Research, 2011
Sarah R Kingsbury1,2, Philip G Conaghan1,2, Michael F McDermott1,21Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds,
Sarah R Kingsbury, Philip G Conaghan, Michael F McDermott   +2 more
doaj  

Contemporary Recurrent Pericarditis Management – Real-World Evidence of Limited Cardiac Magnetic Resonance Imaging Prior to Initiating Rilonacept [PDF]

Contemporary Recurrent Pericarditis Management – Real-World Evidence of Limited Cardiac Magnetic Resonance Imaging Prior to Initiating Rilonacept  Brittany Weber, MD, PhD1, Paul C. Cremer, MD2, Michael S.
Curtis, Allison, Cremer, Paul C., Luis, Sushil A., Paolini, John F., Weber, Brittany, Garshick, Michael S., Raisinghani, Ajit, Klein, Allan L., Parameswaran, Vidhya, RESONANCE Study Group   +9 more
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