Results 21 to 30 of about 7,229 (203)

Rilpivirine in HIV-1-positive women initiating pregnancy: to switch or not to switch?

open access: yes, 2020
International audienceBackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasma concentrations are reduced during second/third trimesters, with a potential risk of viral breakthroughs.
Benoist, Laurence   +416 more
core   +1 more source

Long-Acting Injectable Antiretroviral Therapies for HIV Treatment and Prevention: Clinical Pharmacology, Recent Advances and Future Opportunities. [PDF]

open access: yesJ Clin Pharmacol
Abstract Long‐acting (LA) antiretroviral (ARV) medications represent a significant advancement in the HIV treatment and prevention field. LA ARVs help reduce daily pill burden and thus optimize adherence, which has translated into sustained virologic suppression in persons with HIV, prevention of HIV transmission among those at risk, and improved ...
Dunbar A   +4 more
europepmc   +2 more sources

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV

open access: yesPharmaceuticals, 2020
In the treatment of acquired immune deficiency syndrome (AIDS), the diarylpyrimidine (DAPY) analogs etravirine (ETR) and rilpivirine (RPV) have been widely effective against human immunodeficiency virus (HIV) variants that are resistant to other non ...
Daniel M. Himmel, Eddy Arnold
doaj   +1 more source

Pharmacokinetics and Drug–Drug Interactions of Long-Acting Intramuscular Cabotegravir and Rilpivirine

open access: yes, 2021
Combined antiretroviral treatments have significantly improved the morbidity and mortality related to HIV infection, thus transforming HIV infection into a chronic disease; however, the efficacy of antiretroviral treatments is highly dependent on the ...
Marzolini, C.   +9 more
core   +1 more source

A process for purification of Rilpivirine [PDF]

open access: yes, 2023
The present publication provides a process for the purification of 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile represented by the following structural formula-1.

core   +1 more source

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CABOTEGRAVIR & RILPIVIRINE BY RP HPLC METHOD

open access: yes, 2022
A new method was established for simultaneous estimation of and cabotegravir and rilpivirine by RP-HPLC method. The Phosphate buffer was pH 3.2 and the mobile phase was optimized which consists of Acetonitrile: Phosphate buffer mixed in the ratio of 40 ...
Pindi Shravani, Dr. Nihar Ranjan Das
core   +1 more source

Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women [PDF]

open access: yes, 2016
BACKGROUND: Rilpivirine pharmacokinetics is defined by its absorption, distribution, metabolism, and excretion. Pregnancy can affect these factors by changes in cardiac output, protein binding, volume of distribution, and cytochrome P450 (CYP) 3A4 ...
Smith, Elizabeth   +14 more
core   +1 more source

Use of rilpivirine in HIV-1 infected individuals in routine clinical practice from 2012 to 2017 in France

open access: yes, 2020
International audienceWe assessed virological outcomes of rilpivirine use in France from 2012 to 2017, in three groups of people living with HIV (PLHIV):(1) antiretroviral (ARV)-naïve PLHIV;(2) ARVexperienced PLHIV switching to rilpivirine while failing ...
Potard, Valérie   +3 more
core   +2 more sources

Use of PCR Signal and Therapeutic Drug Monitoring in a Switch Cohort Study to Tenofovir/Emtricitabine/Rilpivirine: A W96 Follow-Up. [PDF]

open access: yesPLoS ONE, 2015
To assess, in a clinical cohort, the efficacy of switching treatment in virologically-suppressed patients to tenofovir/emtricitabine/rilpivirine as a single-tablet regimen (STR) using the PCR signal of the viral load (VL) assay and plasma drug ...
Charlotte Charpentier   +10 more
doaj   +1 more source

Anti-Leukaemic Activity of Rilpivirine Is Mediated by Aurora A Kinase Inhibition

open access: yes, 2023
Acute myeloid leukaemia (AML) affects predominantly elderly people and has an incidence of 1% of all cancers and 2% of all cancer deaths. Despite using intensive chemotherapy and allogeneic stem cell transplantation, the treatment options for AML remain ...
Jennifer H. Martin   +6 more
core   +1 more source

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