Results 61 to 70 of about 200,471 (302)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

New Insight into the Ring Contraction of 2′-Benzyloxyflavanones

Natural Product Communications, 2006
The reactions of 2′-benzyloxyflavanones 9b,c with thallium(III) nitrate or iodobenzene diacetate in the presence of perchloric or sulfuric acid in trimethyl orthoformate was studied.
István Németh, Katalin Gulácsi, Sándor Antus, Sándor Kéki, Miklós Zsuga   +4 more
doaj   +1 more source

Allobetulin and Its Derivatives: Synthesis and Biological Activity

Molecules, 2011
This review covers the chemistry of allobetulin analogs, including their formation by rearrangement from betulin derivatives, their further derivatisation, their fusion with heterocyclic rings, and any further rearrangements of allobetulin compounds ...
Talgat S. Seitembetov, Wim Dehaen, Anastassiya A. Mashentseva   +2 more
doaj   +1 more source

Contractions of Lie algebras and algebraic groups [PDF]

, 2007
Degenerations, contractions and deformations of various algebraic structures play an important role in mathematics and physics. There are many different definitions and special cases of these notions.
Burde, Dietrich
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

2-Benzoyl-4-phenyl-1,2,5-thiadiazol-3(2H)-one 1,1-Dioxide

Molbank
3,5-Diphenyl-4H-1,2,6-thiadiazin-4-one treated with meta-chloroperoxybenzoic acid undergoes an oxidative ring contraction to give 2-benzoyl-4-phenyl-1,2,5-thiadiazol-3(2H)-one 1,1-dioxide in a 29% yield, the structure of which is supported by single ...
Emmanouil Broumidis, Samuel B. H. Patterson, Georgina M. Rosair, Panayiotis A. Koutentis, Andreas S. Kalogirou   +4 more
doaj   +1 more source

Diethyl Pyrrole-2,5-Dicarboxylate

Molbank, 2020
The title compound was obtained in moderate yield by a new and unexpected base-induced ring contraction from a 1,4-thiazine precursor. Its x-ray structure showing hydrogen bonded dimers was compared with those of other crystallographically characterised ...
R. Alan Aitken, Charles Bloomfield, Liam J. R. McGeachie, Alexandra M. Z. Slawin   +3 more
doaj   +1 more source

Fluctuations and differential contraction during regeneration of Hydra vulgaris tissue toroids

, 2012
We studied regenerating bilayered tissue toroids dissected from Hydra vulgaris polyps and relate our macroscopic observations to the dynamics of force-generating mesoscopic cytoskeletal structures.
Belytschko T, Claus Fütterer, Cook R D, Fütterer C, Holtfreter J, Iris Wenzel, Joseph Goldmann, Julia Fischer, Kao-Nung Lin, Kosevich I A, Koth S, Markus Kästner, McDowall A W, Michael Krahe, Mutz E, Orescanin M Qayyum M A Toohey K S Insana M F, Wang N, Wetzel G, Whitehead J, Wolff L, Zhao R   +20 more
core   +1 more source

Modelling protein localisation and positional information in subcellular systems [PDF]

, 2008
Cells and their component structures are highly organised. The correct function of many biological systems relies upon not only temporal control of protein levels but also spatial control of protein localisation within cells.
Tostevin, Filipe John, Tostevin, Filipe John   +1 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source