Results 121 to 130 of about 221,077 (298)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Relationships between field-aligned currents and convection observed by EISCAT and implications concerning the mechanism that produces region-2 currents: Statistical study

open access: yesAnnales Geophysicae
Fluid theories explain the origin of region-2 field-aligned currents as the closure of the ring current, driven itself by the azimuthal pressure gradients generated in the magnetospheric ring plasma by the sunward convection.
Christophe Peymirat, Dominique Fontaine
doaj  

Research on Measures to Limit Short-Circuit Current by Changing the Structure of the Power Grid

open access: yesEnergies
This paper addresses the increasingly severe issue of excessive short-circuit currents brought about by the rapid development of large power grids. The working principles of structural changes in the grid as a means of limiting currents are studied, and ...
Shuqin Sun   +5 more
doaj   +1 more source

Flux-biased mesoscopic rings

open access: yes, 2007
Kinetics of magnetic flux in a thin mesoscopic ring biased by a strong external magnetic field is described equivalently by dynamics of a Brownian particle in a tilted washboard potential. The 'flux velocity', i.e.
Cheung   +12 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The influence of quiet asymmetric magnetosphere on the cutoff rigidities of the main cone [PDF]

open access: yes
Some earlier studies show that cutoff rigidities of cosmic-ray particles in the model magnetospheric fields of internal and external sources have daily variations caused by asymmetry of the magnetic field due to the currents induced at the magnetopause ...
Danilova, O. A., Tyasto, M. I.
core   +1 more source

Hidden quantum pump effects in quantum coherent rings

open access: yes, 2003
Time periodic perturbations of an electron system on a ring are examined. For small frequencies periodic small amplitude perturbations give rise to side band currents which in leading order are inversely proportional to the frequency.
Buttiker, M., Moskalets, M.
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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