Results 91 to 100 of about 355,905 (327)

Rate Constant for the Ring Opening of the 2,2-Difluorocyclopropylcarbinyl Radical [PDF]

open access: yesOrganic Letters, 2000
The rate constant for the unimolecular ring opening of the 2,2-difluorocyclopropylcarbinyl radical was determined via its competitive bimolecular trapping by TEMPO. The value of this rate constant (3.4 x 10(11) s(-)(1) at 99.3 degrees C) is about 500 times larger than that of the parent, unfluorinated radical and about 5 times smaller than that of the ...
, Tian, , Dolbier
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Macrocyclic bis(ureas) as ligands for anion complexation

open access: yesBeilstein Journal of Organic Chemistry, 2014
Two macrocyclic bis(ureas) 1 and 2, both based on diphenylurea, have been synthesized. Compound 1 represents the smaller ring with two ethynylene groups as linkers and 2 the larger ring with two butadiynylene groups.
Claudia Kretschmer   +2 more
doaj   +1 more source

Quantum cohomology of the Lagrangian Grassmannian

open access: yes, 2003
Let V be a symplectic vector space and LG be the Lagrangian Grassmannian which parametrizes maximal isotropic subspaces in V. We give a presentation for the (small) quantum cohomology ring QH^*(LG) and show that its multiplicative structure is determined
Kresch, Andrew, Tamvakis, Harry
core   +1 more source

Euler constants for the ring of $S$-integers of a function field

open access: yesPortugaliae Mathematica, 2007
The Euler constant \gamma may be defined as the limit for n tending to +\infty , of the difference \sum\limits_{j=1}^n\frac1{j}-\log n
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

On the ring of constants of a diagonalizable higher derivation

open access: yesJournal of Pure and Applied Algebra, 1992
Let \(k\) be a field of positive characteristic \(p>0\), let \(q=p^ e\), and let \(\mu_ q\) denote the group scheme of \(q\)-th roots of unity over \(k\). Suppose the \(\mu_ q\) acts linearly on the affine \(n\)-space \(\mathbb{A}^ n\) over \(k\).
Ishibashi, Yasunori, Onoda, Nobuharu
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Home - About - Disclaimer - Privacy