Results 71 to 80 of about 343,735 (322)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Investigating the impact of chemical structures on the photocatalytic degradation rates over ZnO nanorods: An oxidative pathways perspective

open access: yesCatalysis Communications, 2023
Zinc oxide (ZnO) nanorods were coated on glass substrates and used as photocatalysts to evaluate the kinetic behavior of three different aromatic structures: i) single aromatic ring (phenol), ii) poly-aromatic ring (methylene blue), and iii) complex ...
Elie A. Daher   +3 more
doaj  

High-Sensitivity Microwave Sensor Based on an Interdigital-Capacitor-Shaped Defected Ground Structure for Permittivity Characterization

open access: yesSensors, 2019
This study proposes a high-sensitivity microwave sensor based on an interdigital-capacitor-shaped defected ground structure (IDCS-DGS) in a microstrip transmission line for the dielectric characterization of planar materials.
Junho Yeo, Jong-Ig Lee
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

The operator rings of topological symmetric orbifolds and their large N limit

open access: yesJournal of High Energy Physics
We compute the structure constants of topological symmetric orbifold theories up to third order in the large N expansion. The leading order structure constants are dominated by topological metric contractions.
Sujay K. Ashok, Jan Troost
doaj   +1 more source

Additional Factors Affecting the Rate and Mechanism of Ring Opening Reaction [PDF]

open access: yesمجلة التربية والعلم, 2005
The reactions of thiosulphate ion with some bromoalkylamines of structure RR'N-(CH2)n-Br, where n = 2,3,4,5 or 6 and R - R1 - H, methyl, ethyl or isopropyl, were studied kinetically in an aqueous solution at different pH, The kinetic results for these ...
Mahmoud S.Saieed
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Effect of antioxidant activity of caffeic acid with cyclodextrins using ground mixture method

open access: yesAsian Journal of Pharmaceutical Sciences, 2018
In the current study, we prepared a ground mixture (GM) of caffeic acid (CA) with α-cyclodextrin (αCD) and with β-cyclodextrin (βCD), and then comparatively assessed the physicochemical properties and antioxidant capacities of these GMs. Phase solubility
Ryota Shiozawa   +3 more
doaj   +1 more source

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