Results 41 to 50 of about 2,493,787 (249)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Modelling interface factorizations between Landau-Ginzburg models as module functors
Journal of High Energy PhysicsWe study the fusion of B-type interfaces between N = (2, 2) supersymmetric Landau-Ginzburg models. Such interfaces can be described by matrix factorizations of the difference of the superpotentials, and their fusion is modelled by the tensor product of ...
Stefan Fredenhagen
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Splitting fields for torsion-free modules over discrete valuation rings, II
Journal of Algebra, 1977 AbstractLet G be a finite rank torsion-free module over a discrete valuation ring V. A splitting field for G is a subfield K of the quotient field of the completion V∗ of V such that (V∗ ∩ K) ⊗ G is a completely decomposable (V∗ ∩ K)-module. Every such G has a splitting field which is a finitely generated extension of the quotient field Q of V. If K is
openaire +3 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Endomorphism rings and isogenies classes for Drinfeld A-modules of rank 2 over finite fields [PDF]
Comptes Rendus. Mathématique, 2006 For a Drinfeld module of rank 2, we discuss many analogy points with elliptic curves. More precisely, we study the characteristic polynomial of a Drinfeld module of rank 2 and use it to calculate the number of isogeny classes for such modules.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Journal of Mathematics, 2022 The LA‐module is a nonassociative structure that extends modules over a nonassociative ring known as left almost rings (LA‐rings). Because of peculiar characteristics of LA‐ring and its inception into noncommutative and nonassociative theory, drew the attention of many researchers over the last decade.
Asima Razzaque, Inayatur Rehman
openaire +2 more sources