Advanced Science, EarlyView.Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
Nonsense-mediated mRNA decay factors target short poly(A)-tailed mRNAs lacking a premature termination codon. [PDF]
Nat CommunGouhier T, Saveanu C, Badis G.
europepmc +1 more source
A Study of Rip Current Warning Dissemination Methods
Viable, Healthy and Safe CommunitiesRip currents are a global public health concern, which represent a hazard when swimmers become caught and panic or become exhausted when attempting to swim against the current and back to shore, leading to exhaustion ...
Scaman, Alexandra Carol Lynn
core
Advanced Science, EarlyView.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Public Health Promotion Through Language Learning: Improving Migrants' Australian Beach Safety Knowledge Through a Reading Exercise for English Language Proficiency Tests. [PDF]
Health Promot J AustrShibata M +5 more
europepmc +1 more source
A Review of Failure Modes and Safety Strategies of Lithium‐Ion Batteries from Materials to Systems
Advanced Science, EarlyView.A cascade‐aware framework is presented for lithium‐ion battery safety, linking thermal runaway initiation, acceleration, runaway reaction, and propagation with material‐, cell/pack‐, and system‐level interventions. By integrating failure mechanisms, quantitative safety indicators, and staged interception strategies, this review highlights how safer ...
Jin Hyeok Yang +8 more
wiley +1 more source
Collapsing Perisomatic Inhibition Leads to Epileptic Fast-Ripple Oscillations Caused by Pseudosynchronous Firing of CA3 Pyramidal Neurons. [PDF]
J NeurosciSchlingloff D +3 more
europepmc +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Research Progress on Antivirulence Agents Targeting the Accessory Gene Regulator (Agr) System of <i>Staphylococcus Aureus</i>. [PDF]
Infect Drug ResistChen L, Huang M, Chen Y, Lin Y, Cong Y.
europepmc +1 more source
Advanced Science, EarlyView.A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky +15 more
wiley +1 more source