Results 231 to 240 of about 19,353 (245)

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

FEBS Letters, 2020
Receptor‐interacting serine/threonine‐protein kinase 3 (RIPK3) is a central protein in necroptosis with great potential as a target for treating necroptosis‐associated diseases, such as Crohn's disease. However, blockade of RIPK3 kinase activity leads to unexpected RIPK3‐initiated apoptosis.
Wenjuan Li, Hengxiao Ni, Shaofeng Wu, Shang Han, Chang'an Chen, Li Li, Yunzhan Li, Fu Gui, Jiahuai Han, Xianming Deng   +9 more
openaire   +2 more sources

UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity

Cell Death Discovery
Ultraviolet B (UVB) is recognized for inducing inflammation and death of keratinocytes through the activation of death receptors and pattern recognition receptors (PRRs).
Tairan Hu, Xiaodong Lai, Li Li, Yi Li, Meng Wang, Haini Zhang, Yan Yang, Chong Zhang, Yan Yan, Baoxi Wang   +9 more
semanticscholar   +1 more source

Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice.

International Immunopharmacology, 2023
Necroptosis is a necrotic form of regulated cell death, which is primarily mediated by the receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like (MLKL) pathway in a caspase-independent manner.
Qiuyan Liang, Zi-jian Shi, Tao Yuan, Sisi Chen, Ya-ping Li, Hong-rui Zhang, Yi-ping You, Rong Xu, Li‐hui Xu, Bo Hu, D. Ouyang, Qing-bing Zha, Xian-hui He   +12 more
semanticscholar   +1 more source

Extracellular RIPK3 Acts as a Damage-Associated Molecular Pattern to Exaggerate Cardiac Ischemia/Reperfusion Injury

Circulation
BACKGROUND: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease. Currently, there is no effective therapy for reducing cardiac I/R injury. Damage-associated molecular patterns are endogenous
Wenjia Zhang, Junxia Zhang, Zeyuan Wang, Ting Li, Changyun Liu, Xuya Kang, X. Cui, Jingli Yang, Huilin Qu, Jiaxin Duanmu, Ying Peng, Kai Wang, Li Jin, Peng Xie, Wen Zheng, Haibao Shang, Yahan Liu, Zhuang Tian, Zhenyu Liu, Ye Jin, Yingjia Li, Nan Li, Xiaozhen Zhuo, Yue Wu, Xiaolu Shi, Runhao Ma, Yueshen Sun, Kai Zhang, Xiangming Fang, Xiaomin Hu, Erdan Dong, Shuyang Zhang, Yan Zhang   +32 more
semanticscholar   +1 more source

RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling.

Metabolism: Clinical and Experimental
BACKGROUND Receptor-interacting protein kinase (RIPK)3 is an essential molecule for necroptosis and its role in kidney fibrosis has been investigated using various kidney injury models.
J. Kang, N. Cho, S. Lee, Jeong Geon Lee, Ji-Hye Lee, Jawoon Yi, Min Sun Choi, Samel Park, H. Gil, Joon Cheol Oh, S. Son, Mi Ju Park, Jong-Seok Moon, Donghyeong Lee, So-Young Kim, Seung-Hoon Yang, Sang Soo Kim, Eun Soo Lee, Choon Hee Chung, Jihwan Parkf, Eun Young Lee   +20 more
semanticscholar   +1 more source

A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis

Proceedings of the National Academy of Sciences of the United States of America
Significance We revealed a mechanism in which a viral protein promotes the direct RIPK3 activation leading to inflammatory necroptosis and pathogenesis.
Shufen Li, Hao Li, Zhenxing Zhou, Meidi Ye, Yifei Wang, Wenqing Li, Zhenqiong Guan, Zihan Guan, Chongtao Zhang, Yu-lan Zhang, Wei Liu, Ke Peng   +11 more
semanticscholar   +1 more source

RIPK3 coordinates RHIM domain-dependent antiviral inflammatory transcription in neurons.

Science Signaling
Neurons are postmitotic, nonregenerative cells that have evolved fine-tuned immunological responses to maintain life-long cellular integrity, including resistance to common programmed cell death pathways such as necroptosis.
Sigal B. Kofman, Lan H Chu, Joshua M Ames, Suny Dayane Chavarria, Katrina Lichauco, Brian P. Daniels, Andrew Oberst   +6 more
semanticscholar   +1 more source

Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease.

Neurochemistry International
Parkinson's disease (PD) is a neurodegenerative disorder triggered by the loss of dopaminergic neurons in the substantia nigra (SN). Recent studies have demonstrated that necroptosis is involved in dopaminergic neuronal cell death and the resulting ...
Jin‐Sun Park, Y. Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Kim   +5 more
semanticscholar   +1 more source

Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling

2018
Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes and cell lysis.
Joshua D, Webster, Margaret, Solon, Susan, Haller, Kim, Newton   +3 more
openaire   +2 more sources

Down-regulation of RIPK3 prevents depression-like behaviors by restoring the synaptic plasticity and suppressing neuronal loss.

Journal of Affective Disorders
BACKGROUND The excessive secretion of glucocorticoids resulting from the overactivation of the hypothalamic-pituitary-adrenal axis is a crucial factor in the pathogenesis of depression.
Xinxin Xu, Yuxing Yan, Zhuo Yang, Tao Zhang   +3 more
semanticscholar   +1 more source