Results 231 to 240 of about 17,129 (242)

Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1. [PDF]

Nat Commun
Polonio P, López-Alonso JP, Jiang H, Andrés-Campos S, Escobedo-González FC, Titaux-Delgado GA, Ubarretxena-Belandia I, Mompeán M.   +7 more
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RIPK1 and RIPK3 in antibacterial defence

Biochemical Society Transactions, 2022
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
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Mechanisms of RIPK3‐induced inflammation

Immunology & Cell Biology, 2017
Receptor‐interacting protein kinase 3 (RIP3/RIPK3) is a multifunctional regulator of cell death and inflammation. It controls signalling downstream of the tumor necrosis factor (TNF) receptor family, DNA‐dependent activator of IFN‐regulatory factors (DAI) and toll‐like receptors (TLRs).
Inbar Shlomovitz, Sefi Zargrian, Motti Gerlic   +2 more
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Ring closure strategy leads to potent RIPK3 inhibitors

European Journal of Medicinal Chemistry, 2021
Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necroptosis. In this report, we describe the design, synthesis,
Shuwei, Wu, Chen, Xu, Kaijiang, Xia, Yu, Lin, Sheng, Tian, Haikuo, Ma, Yuting, Ji, Fang, Zhu, Sudan, He, Xiaohu, Zhang   +9 more
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c-Abl activates RIPK3 signaling in Gaucher disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. Heterozygous GBA1 variants are a major genetic risk factor for developing Parkinson's disease.
Yañez Henríquez, María José, Campos, F., Marín Marín, Tamara Alejandra, Klein Posternack, Andrés David, Futerman, A. H., Álvarez, Alejandra R., Zanlungo Matsuhiro, Silvana   +6 more
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Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Trends in Pharmacological Sciences, 2020
The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity.
Martens, Sofie, Hofmans, Sam, Declercq, Wim, Augustyns, Koen, Vandenabeele, Peter   +4 more
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Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

FEBS Letters, 2020
Receptor‐interacting serine/threonine‐protein kinase 3 (RIPK3) is a central protein in necroptosis with great potential as a target for treating necroptosis‐associated diseases, such as Crohn's disease. However, blockade of RIPK3 kinase activity leads to unexpected RIPK3‐initiated apoptosis.
Wenjuan Li, Hengxiao Ni, Shaofeng Wu, Shang Han, Chang'an Chen, Li Li, Yunzhan Li, Fu Gui, Jiahuai Han, Xianming Deng   +9 more
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Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling

2018
Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes and cell lysis.
Joshua D, Webster, Margaret, Solon, Susan, Haller, Kim, Newton   +3 more
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RIPK1 and RIPK3 form mosaic necrosomes

Nature Cell Biology, 2022
Weiwei Qi, Junying Yuan
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R.E.P.U.T.A.T.I.O.N (RIPK3’s version) - RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection

While recent work has identified roles for immune mediators in the regulation of neural activity, the capacity for cell intrinsic innate immune signaling within neurons to influence neurotransmission remains poorly understood. However, the existing evidence linking immune signaling with neuronal function suggests that modulation of neurotransmission ...
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