Results 101 to 110 of about 4,312 (262)
Influence of Buoyancy Tank on Axial Vibration of Freestanding Rigid Riser
Shiyou jixie, 2017 The complex marine environment easily leads to periodic changes in buoyancy of buoyancy tank on freestanding riser system, resulting in axial vibration of rigid riser. When the buoyancy tank frequency is the same or close to the inherent frequency of the
Zhou Xingkun, Duan Menglan
doaj
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The New Riser Strength Check Technology for Shallow Cold Sea Oilfield Based on Finite Element Method
Shiyou jixie, 2017 To address the riser stress check issue caused by the complicated subarctic Sakhalin sea area conditions such as high sea wind, ocean current, sea wave and sea ice thickness, on the basis of conventional riser stress check, and considering the sea ice ...
Niu Chengcheng +3 more
doaj
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Ensuring Good Transferability from Pilot- to Large-Scale Optimized Biotech Bubble Column Designs. [PDF]
Bioengineering (Basel)Link C, Bromley J, Martin M, Takors R.
europepmc +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Dynamic CEA kinetics as a prognostic biomarker for HER2-negative advanced gastric cancer treated with chemoimmunotherapy. [PDF]
BMC CancerYu S, Sun Y, Zhou J, Sun C, Wu Z.
europepmc +1 more source