Results 81 to 90 of about 1,047 (208)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Analysis of Fatigue Monitoring of Deepwater Drilling Riser
Shiyou jixie, 2017 The riser is the key equipment for deepwater drilling, which is prone to fatigue damage in harsh deepwater environment, so it is very important to monitor the fatigue of deepwater riser.
Li Qingpei +5 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Application of Mudline Tubing Hanger in Dry Tree Well on TLP Platform
Shiyou jixie, 2018 Reducing the tension of the TTR riser of the TLP platform could help to reduce the platform load and size. The overall and local tension force analyses of the TTR system indicate that the gravity of the TTR riser does not affect the top tension of the ...
Wu Guang
doaj
Oil & Gas Science and Technology, 2009 This paper discusses the development of a 14-inch ID high-pressure hybrid riser (10 000 psi) for surface BOP drilling in ultra-deep water (10 000 ft). The high-pressure hybrid riser system is obtained by adapting and combining two existing technologies,
Persent E. +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Dynamic Characteristic Study of Riser with Complex Pre-stress Distribution
Polish Maritime Research, 2019 In this study, the dynamic characteristic problem of riser structure with complex pre-stress distribution is investigated. At first, the differential equation of the riser structure with complex pre-stress distribution is derived.
Chen Luyun, Yi Hong
doaj +1 more source
, 2008 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources