Results 131 to 140 of about 36,414,097 (422)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

How to make risk analysis an effective guide to managing risk [PDF]

open access: yes
John Lathrop, Irem Dikmen, Emma Soane and Terje Aven helped create the Risk Analysis Quality Test and discuss how risk analysis can be improved in an ...
Aven, Terje   +3 more
core  

Risk Management Analysis on the Car Drivers in Indonesia [PDF]

open access: yes, 2015
Car drivers in Indonesia will always face many kinds of risks. This research contains the context determination of this research, identifies all the significant risks, measures the frequency and impact of all the risks, draws all the identified risks in ...
Kuntohadi, H. (Hendro)   +2 more
core  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Model Spaces for Risk Measures [PDF]

open access: yesInsurance: Mathematics and Economics, Vol. 77, pp. 150-165 (2017), 2017
We show how risk measures originally defined in a model free framework in terms of acceptance sets and reference assets imply a meaningful underlying probability structure. Hereafter we construct a maximal domain of definition of the risk measure respecting the underlying ambiguity profile.
arxiv  

Uncertainty and risk: politics and analysis [PDF]

open access: yes, 2006
In environmental and sustainable development policy issues, and in infrastructural megaprojects and issues of innovative medical technologies as well, public authorities face emergent complexity, high value diversity, difficult-to-structure problems ...
Hoppe, Robert
core   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Quantitative Cost and Schedule Risk Analysis of Nuclear Waste Storage [PDF]

open access: yesarXiv, 2019
This study provides an independent, outside-in estimate of the cost and schedule risks of nuclear waste storage projects. Based on a reference class of 216 past, comparable projects, risk of cost overrun was found to be 202% or less, with 80% certainty, i.e., 20% risk of an overrun above 202%. Based on a reference class of 200 past, comparable projects,
arxiv  

Risk as Analysis and Risk as Feelings: Some Thoughts about Affect, Reason, Risk, and Rationality

open access: yesRisk Analysis, 2004
Modern theories in cognitive psychology and neuroscience indicate that there are two fundamental ways in which human beings comprehend risk. The “analytic system” uses algorithms and normative rules, such as probability calculus, formal logic, and risk ...
P. Slovic   +3 more
semanticscholar   +1 more source

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