Results 91 to 100 of about 1,996,867 (356)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Engineering Geology Study For Planning And Construction Of Tirana-Elbasani Motorway [PDF]

, 2013
In this paper are treated the results of the engineering geological study done for motorway construction purpose of Tirana-Elbasani cities in feasibility and project idea phases.
Ylber Muceku
core  

Can dissonance engineering improve risk analysis of human–machine systems? [PDF]

, 2017
The paper discusses dissonance engineering and its application to risk analysis of human–machine systems. Dissonance engineering relates to sciences and technologies relevant to dissonances, defined as conflicts between knowledge.
A Hunter, A Ouedraogo, C Cacciabue, E Aïmeur, E Hollnagel, EE Telci, F Dehais, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F Vanderhaegen, F. Vanderhaegen, G-Y Kervern, J Rushby, JJ Gibson, K Chorlton, K Sedki, L Festinger, L McCay-Peet, M Massironi, O. Carsten, OECD International Transport Forum, P Polet, P Polet, P Rateau, R Westrum, S Zieba, S Zieba, T Inagaki, T-Y Chen, U Yozgat, V Rouhiainen, W Ben Yahia   +40 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Photocatalytic Degradation of Antibiotics Using Nanomaterials: Mechanisms, Applications, and Future Perspectives

Nanomaterials
Widespread antibiotic residues in aquatic environments pose escalating threats to ecological stability and human health, highlighting the urgent demand for effective remediation strategies.
Jianwei Liu, Hongwei Ruan, Pengfei Duan, Peng Shao, Yang Zhou, Ying Wang, Yudi Chen, Zhiyong Yan, Yang Liu   +8 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Selection of Optimal Portfolio by Use of Risk Diversification Method [PDF]

The paper will discuss how securities investors can protect themselves from risk through diversification. There will be proposals how investors should structure their portfolio, i.e.
Ivan Kristek, Ivo Mijoc, Martina Bris
core  

Mengapa Proyek Perangkat Lunak Gagal (Penerapan Manajemen Resiko Dalam Proyek Perangkat Lunak) [PDF]

, 2010
The greater and problems complex of software development project enables the event of failure. Risk management is an approach to guide minimization or lessens the failure impact.
Afrizal, Y. (Yasmi)
core  

Countering Social Engineering through Social Media: An Enterprise Security Perspective

, 2015
The increasing threat of social engineers targeting social media channels to advance their attack effectiveness on company data has seen many organizations introducing initiatives to better understand these vulnerabilities.
C Colwill, E Franchi, F Amigorena, J Bell, JC Meister, K Wong, NAG Arachchilage, RJ Rudman, W He   +8 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source