Results 81 to 90 of about 31,395,953 (255)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Risk analysis of performance measure forecasts in road safety engineering [PDF]

, 2014
This research contributes to improved risk analysis of performance measure forecasts in road safety engineering by designing and applying a method to characterize uncertainty associated with forecast input data in cases where input uncertainty is not ...
Milligan, Craig Alexander
core  

Bond graph analysis in robust engineering design [PDF]

, 2000
Within engineering design, optimization often involves building models of working systems to improve design objectives such as performance, reliability and cost.
GABBRIELLI R., de Mast, J., Does, R.J.M.M., BRAGLIA, MARCELLO, van den Heuvel, E.R., BRAGLIA M., Heuvel, van den, E.R., Bates, RA, YANG, Zhenlin, BEVILACQUA M., Atherton, MA, GABBRIELLI, ROBERTO, Bates, R. A., Yang, Z., Schippers, W.A.J., Atherton, M. A., Mast, de, J., Does, R.J.M.M.; id_orcid, BEVILACQUA, MAURIZIO, Wu, Shuo-jye; Tsai, Tzong-ru, Xie, M., Gaudoin, O., Wu, Shuo-jye, M. A. Atherton, R. A. Bates   +24 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Engineering Vanderbilt; Vol. 51 No. 01, 2010

, 2010
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Page 2 from the dean * Page 6 cover story From Startups to Success: VUSE Engineers Thrive as Entrepreneurs in Businesses Large ...
Vanderbilt University. School of Engineering
core  

Photocatalytic Degradation of Antibiotics Using Nanomaterials: Mechanisms, Applications, and Future Perspectives

Nanomaterials
Widespread antibiotic residues in aquatic environments pose escalating threats to ecological stability and human health, highlighting the urgent demand for effective remediation strategies.
Jianwei Liu, Hongwei Ruan, Pengfei Duan, Peng Shao, Yang Zhou, Ying Wang, Yudi Chen, Zhiyong Yan, Yang Liu   +8 more
doaj   +1 more source

Optimizing Wireless Sensor Network Installations by Visibility Analysis on 3D Point Clouds

ISPRS International Journal of Geo-Information, 2019
In this paper, a MATLAB tool for the automatic detection of the best locations to install a wireless sensor network (WSN) is presented. The implemented code works directly on high-resolution 3D point clouds and aims to help in positioning sensors that ...
Teresa Gracchi, Giovanni Gigli, François Noël, Michel Jaboyedoff, Claudia Madiai, Nicola Casagli   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Project risk analysis and management guide

NoThe third edition of the Project Risk Analysis and Management Guide brings together a diverse range of risk practitioners in terms of both their role (e.g. advisory, academic and delivery) and sector (e.g.
Rye, Sara, Association for Project Management Risk Interest Network   +1 more
core   +2 more sources

Integral approach to risk analysis and value engineering [PDF]

Tehnika, 2020
Value analysis and engineering, on one hand, and risk analysis, on the other, are two very significant approaches whose application is widely accepted in various scientific fields.
Anđelić Ognjen R., Rakićević Zoran M., Nikolić Valentina N.   +2 more
doaj