Results 61 to 70 of about 485,127 (266)
Integral approach to risk analysis and value engineering [PDF]
Tehnika, 2020 Value analysis and engineering, on one hand, and risk analysis, on the other, are two very significant approaches whose application is widely accepted in various scientific fields.
Anđelić Ognjen R. +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Optimizing Wireless Sensor Network Installations by Visibility Analysis on 3D Point Clouds
ISPRS International Journal of Geo-Information, 2019 In this paper, a MATLAB tool for the automatic detection of the best locations to install a wireless sensor network (WSN) is presented. The implemented code works directly on high-resolution 3D point clouds and aims to help in positioning sensors that ...
Teresa Gracchi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
NanomaterialsWidespread antibiotic residues in aquatic environments pose escalating threats to ecological stability and human health, highlighting the urgent demand for effective remediation strategies.
Jianwei Liu +8 more
doaj +1 more source
Recent advances in Raman technology with applications in agriculture, food and biosystems: A review
Artificial Intelligence in Agriculture, 2019 Raman technology, which covers Raman spectroscopy (RS) and its various derivative methods, has been widely applied in detection of various substances in agriculture, food and biosystems.
Shizhuang Weng +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
IEEE AccessAssessing whether data-driven photovoltaic (PV) models can generalize beyond the plants used for training remains a critical challenge when operational data are available for only a limited number of installations.
Andre Luis Ferreira Marques +3 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Importance of Hydraulic Structures for Society: Quay Walls and Dikes in the Netherlands
Civil Engineering Dimension, 2015 Since mankind exists, men have undertaken engineering activities to make their life more pleasant and secure. However this has not been an easy task, especially in the past. The knowledge of mathematics and physics to describe engineering problems became
de Gijt J.G.
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