Results 51 to 60 of about 29,863,978 (304)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mitigating Blast Hazards: Experimental Evaluation of Anti-Shatter Films and Catcher-Cable Systems on Conventional Windows

Buildings
In light of terrorist attacks and accidents, the need for structural protection against explosive events has increased significantly in recent decades. Conventional unprotected windows pose a particularly high risk of injury to building occupants due to ...
Matthias Andrae, Jan Dirk van der Woerd, Matthias Wagner, Achim Pietzsch, Norbert Gebbeken   +4 more
doaj   +1 more source

System Safety Modeling of Alternative Geofencing Configurations for small UAS

International Journal of Aviation, Aeronautics, and Aerospace, 2016
As is well known, the integration of small Unmanned Aircraft Systems (sUAS) or “drones” into the National Airspace System (NAS) has captured significant industry, academic, regulatory and media attention.
James T. Luxhoj
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

SABTR: semantic analysis-based tourism recommendation

Frontiers in Physics
Online tourism spot recommendations, as a key component of tourism services, aim to present travel options that align with users’ personal preferences. However, current recommendation systems often underperform due to the sparsity of tourism data and the
Jiao Li, Jiao Li, Huajian Xue, Huajian Xue, Qigui Tang, Hailiang Wang, Tieliang Gao, Tieliang Gao   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Behavioral Aspects of Population Mobility Following a CBRN Event and Their Implications for Economic Consequence Analysis

International Journal of Disaster Risk Science
Chemical, biological, radiological, and nuclear (CBRN) events can take a catastrophic toll on human life, the environment, and the economy. This article first presents the beginnings of a framework for the analysis of behavioral aspects of population ...
Adam Rose, Bess Djavadi
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source