Results 51 to 60 of about 31,395,953 (255)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mitigating Blast Hazards: Experimental Evaluation of Anti-Shatter Films and Catcher-Cable Systems on Conventional Windows

Buildings
In light of terrorist attacks and accidents, the need for structural protection against explosive events has increased significantly in recent decades. Conventional unprotected windows pose a particularly high risk of injury to building occupants due to ...
Matthias Andrae, Jan Dirk van der Woerd, Matthias Wagner, Achim Pietzsch, Norbert Gebbeken   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Is Risk Analysis Scientific?

, 2014
This article discusses to what extent risk analysis is scientific in view of a set of commonly used definitions and criteria. We consider scientific knowledge to be characterized by its subject matter, its success in developing the best available ...
Aven, Terje, Hansson, Sven Ove,
core   +1 more source

System Safety Modeling of Alternative Geofencing Configurations for small UAS

International Journal of Aviation, Aeronautics, and Aerospace, 2016
As is well known, the integration of small Unmanned Aircraft Systems (sUAS) or “drones” into the National Airspace System (NAS) has captured significant industry, academic, regulatory and media attention.
James T. Luxhoj
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

How to Perform an Ethical Risk Analysis (eRA)

, 2018
Ethical analysis is often needed in the preparation of policy decisions on risk. A three-step method is proposed for performing an ethical risk analysis (eRA).
Sven Ove Hansson, Hansson, Sven Ove,
core   +1 more source

Integration of computer aided design analysis into the engineering design process for use by engineering designers [PDF]

, 2013
When developing products, engineering designers often face the problem that their candidate for a technical solution, ranging from a concept to a detailed design, needs to be analyzed by a design analyst before it is approved or rejected and the ...
Eriksson, Martin,, Håkan Petersson, Motte, Damien,, Petersson, Håkan,, Robert Bjärnemo, Bjärnemo, Robert,, Eriksson, Martin, Petersson, Håkan, Damien Motte, Martin Eriksson, Bjärnemo, Robert, Motte, Damien, Lund University.   +12 more
core   +1 more source

SABTR: semantic analysis-based tourism recommendation

Frontiers in Physics
Online tourism spot recommendations, as a key component of tourism services, aim to present travel options that align with users’ personal preferences. However, current recommendation systems often underperform due to the sparsity of tourism data and the
Jiao Li, Jiao Li, Huajian Xue, Huajian Xue, Qigui Tang, Hailiang Wang, Tieliang Gao, Tieliang Gao   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source