Results 41 to 50 of about 31,395,953 (255)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Risk Analysis Techniques in Construction Engineering Projects [PDF]
Journal of Risk Analysis and Crisis Response (JRACR), 2012 There is a great deal of risk analysis techniques and tools available for the management of risks. In principle, each risk analysis technique has its strengths and weaknesses.
Daniel Baloi
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Resilience engineering for socio-technical risk analysis. Application in neuro-surgery
, 2018 Healthcare practitioners are generally forced to adapt their actions to cope with the complexity of daily conditions, taking advantage of their inherent potential for resilient performance. Following the principles of Resilience Engineering, this article
Bilotta, Federico +3 more
core +1 more source
Review article: Climate change impacts on dam safety [PDF]
Natural Hazards and Earth System Sciences, 2018 Dams as well as protective dikes and levees are critical infrastructures whose associated risk must be properly managed in a continuous and updated process.
J. Fluixá-Sanmartín +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Risk of large oil spills: a statistical analysis in the aftermath of Deepwater Horizon
, 2012 The oil spill in the Gulf of Mexico that followed the explosion of the exploration platform Deepwater Horizon on 20 April 2010 was the largest accidental oil spill so far.
Eckle, Petrissa (author) +2 more
core +1 more source