Results 41 to 50 of about 29,863,978 (304)
Eliciting and combining decision criteria using a limited palette of utility functions and uncertainty distributions: illustrated by application to pest risk analysis [PDF]
, 2013 Utility functions in the form of tables or matrices have often been used to combine discretely rated decision-making criteria. Matrix elements are usually specified individually, so no one rule or principle can be easily stated for the utility function ...
van der Gaag, Dirk Jan +15 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Review article: Climate change impacts on dam safety [PDF]
Natural Hazards and Earth System Sciences, 2018 Dams as well as protective dikes and levees are critical infrastructures whose associated risk must be properly managed in a continuous and updated process.
J. Fluixá-Sanmartín +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
, 2014 This article discusses to what extent risk analysis is scientific in view of a set of commonly used definitions and criteria. We consider scientific knowledge to be characterized by its subject matter, its success in developing the best available ...
Aven, Terje, Hansson, Sven Ove,
core +1 more source
Modelling production ramp-up of engineering products [PDF]
, 2010 Companies that introduce new products quickly have been shown to be better performers. The effectiveness of the new product introduction process is critical to their performance. Production ramp-up is a necessary phase of new product introduction, and
Roberts, S. +11 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Energies, 2021 Global efforts to tame CO2 emissions include the use of renewable energy sources, such as geo-energy harnessing. However, injecting pressurised fluids into the deep underground can induce earthquakes, hence converting CO2-related risk into seismic risk ...
Arnaud Mignan +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Project risk analysis and management guide
NoThe third edition of the Project Risk Analysis and Management Guide brings together a diverse range of risk practitioners in terms of both their role (e.g. advisory, academic and delivery) and sector (e.g.
Rye, Sara +1 more
core +3 more sources