Results 71 to 80 of about 29,863,978 (304)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genomic Landscape and Antimicrobial Resistance of Listeria monocytogenes in Retail Chicken in Qingdao, China

Foods
Listeria monocytogenes (L. monocytogenes) is an important foodborne pathogen that poses great risks to food safety and public health, and knowledge about its presence and diversity in potential sources is crucial for effectively tracking and controlling ...
Wei Wang, Yao Zhong, Juntao Jia, Lidan Ma, Yan Lu, Qiushui Wang, Lijuan Gao, Jijuan Cao, Yinping Dong, Qiuyue Zheng, Jing Xiao   +10 more
doaj   +1 more source

Risk-based valuations and performance analysis for life insurance contracts

, 2017
The project intends to develop a methodological framework for a comprehensive analysis of both demographic and financial risks in life insurance contracts, based on Value at Risk (VaR) methodologies and able to address the complex equilibrium between ...
rosa cocozza
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Integral approach to risk analysis and value engineering [PDF]

Tehnika, 2020
Value analysis and engineering, on one hand, and risk analysis, on the other, are two very significant approaches whose application is widely accepted in various scientific fields.
Anđelić Ognjen R., Rakićević Zoran M., Nikolić Valentina N.   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Photocatalytic Degradation of Antibiotics Using Nanomaterials: Mechanisms, Applications, and Future Perspectives

Nanomaterials
Widespread antibiotic residues in aquatic environments pose escalating threats to ecological stability and human health, highlighting the urgent demand for effective remediation strategies.
Jianwei Liu, Hongwei Ruan, Pengfei Duan, Peng Shao, Yang Zhou, Ying Wang, Yudi Chen, Zhiyong Yan, Yang Liu   +8 more
doaj   +1 more source

Optimizing Wireless Sensor Network Installations by Visibility Analysis on 3D Point Clouds

ISPRS International Journal of Geo-Information, 2019
In this paper, a MATLAB tool for the automatic detection of the best locations to install a wireless sensor network (WSN) is presented. The implemented code works directly on high-resolution 3D point clouds and aims to help in positioning sensors that ...
Teresa Gracchi, Giovanni Gigli, François Noël, Michel Jaboyedoff, Claudia Madiai, Nicola Casagli   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Cross-Plant Transfer Assessment of Photovoltaic Performance Using Data-Driven Models and a Normalized Technical Factor

IEEE Access
Assessing whether data-driven photovoltaic (PV) models can generalize beyond the plants used for training remains a critical challenge when operational data are available for only a limited number of installations.
Andre Luis Ferreira Marques, Ricardo Sbragio, Pedro Luiz Pizzigatti Correa, Marcelo Ramos Martins   +3 more
doaj   +1 more source