Results 101 to 110 of about 4,082,751 (347)

Fuzzy Reasoning for the analysis of risks in geotechnical engineering Application to a French Case [PDF]

open access: yes, 1997
The analysis of risks induced by unstable cliffs is one of the major and important tasks in geotechnieal engineering, This analysis should take into account the fact that some engineering parameters that are necessary for any risk analysts around ...
Didier, Christophe   +2 more
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Ethical Issues in Engineering Models: Personal Reflections [PDF]

open access: yes
I start this contribution with an overview of my personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; these case studies employ simulation models.
Kleijnen, Jack P.C.
core   +1 more source

PEMBUATAN PETA MIKROZONASI GEMPA KOTA SEMARANG MELALUI PENGEMBANGAN PROGRAM SEISMIC HAZARD DENGAN MEMPERTIMBANGKAN KONDISI FRAGILITY BANGUNAN [PDF]

open access: yes, 2015
The new Indonesian code for building design, SNI 1726:2012, has been issued recently. It follows the concept of Risk-Adjusted Maximum Considered Earthquake MCE R used by ASCE 7-10 and it provides maps of MCE R for the whole Indonesian Country ...
Irsyam, Masyhur   +2 more
core  

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

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