Results 41 to 50 of about 1,996,867 (356)

Review article: Climate change impacts on dam safety [PDF]

Natural Hazards and Earth System Sciences, 2018
Dams as well as protective dikes and levees are critical infrastructures whose associated risk must be properly managed in a continuous and updated process.
J. Fluixá-Sanmartín, L. Altarejos-García, A. Morales-Torres, I. Escuder-Bueno   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phenomenological Nondimensional Parameter Decomposition to Enhance the Use of Simulation Modeling in Fire Probabilistic Risk Assessment of Nuclear Power Plants

Journal of Nuclear Engineering
Simulation modeling is crucial in support of probabilistic risk assessment (PRA) for nuclear power plants (NPPs). There is a challenge, however, associated with simulation modeling that relates to the time and resources required for collecting data to ...
Sari Alkhatib, Tatsuya Sakurahara, Seyed Reihani, Ernest Kee, Brian Ratte, Kristin Kaspar, Sean Hunt, Zahra Mohaghegh   +7 more
doaj   +1 more source

Comprehensive Survey of Seismic Hazard at Geothermal Sites by a Meta-Analysis of the Underground Feedback Activation Parameter a_fb

Energies, 2021
Global efforts to tame CO2 emissions include the use of renewable energy sources, such as geo-energy harnessing. However, injecting pressurised fluids into the deep underground can induce earthquakes, hence converting CO2-related risk into seismic risk ...
Arnaud Mignan, Marco Broccardo, Ziqi Wang   +2 more
doaj   +1 more source

Contractor’s Risk Analysis of Engineering Procurement and Construction (EPC) Contracts Using Ontological Semantic Model and Bi-Long Short-Term Memory (LSTM) Technology [PDF]

, 2022
So-Won Choi, Eul‐Bum Lee
openalex   +1 more source

EU-NICE, Eurasian University Network for International Cooperation in Earthquakes [PDF]

, 2012
Despite the remarkable scientific advancements of earthquake engineering and seismology in many countries, seismic risk is still growing at a high rate in the world’s most vulnerable communities.
Braga, F., Capelli, M., Cecchini, A., Dixit, A., Dost-Safi, M., Faggella, M., Gigliotti, R., Kumar, H., Laterza, M., Limkatanyu, S., Lodi, S., Lukkunaprasit, P., Monti, G., Rahman, Z., Salvatore, W., Spacone, E., Subedi, J., Triantafillou, T., Varum, H., Xiao, Y., Yingmin, L.   +20 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source