Results 41 to 50 of about 539,954 (312)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Farmers’ Willingness to Pay for Agricultural Insurance in Kulon Progo [PDF]
SHS Web of ConferencesThis study explores farmers’ willingness to pay (WTP) for agricultural insurance in Kulon Progo, Indonesia, and examines how their perceptions of agricultural insurance influence this willingness. With rice farming exposed to various risks such as pests,
Ristya Aminda Fadilla +6 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Uncertainty in incinerator and landfill risk assessments [PDF]
, 2006 The aim of this thesis is the development of a framework for the systematic appraisal and communication of uncertainty in incinerator and landfill human health risk assessments. This aspiration has been in response to finding a limited and ambiguous use
Ganatsiou, Joanna
core
, 2009 Probabilistic risk analysis aims to assess the safety risk of a system so that actions can then be taken to improve safety. Uncertainty however always exists in modelling. For more informed decision making, uncertainty in the outputs of the model must be
Cheng, Doasheng, Cheng, Daosheng
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Interactions between apparently ‘primary’ weather-driven hazards and their cost
Environmental Research Letters, 2015 A statistical analysis of the largest weather-driven hazards in the UK contradicts the typical view that each predominates in distinct events that do not interact with those of other hazard types (i.e., are ‘primary’); this potentially has implications ...
J K Hillier +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Locking-Out Uncertainty: Conflict and Risk in Sydney’s Night-Time Economy
, 2020 This chapter considers the tension between risk, pleasure, and uncertainty in the context of Sydney nightlife. Specifically, it tracks the New South Wales (NSW) government’s recasting of a night-time economy based on neoliberal market freedoms ...
Wadds, Phillip +5 more
core +1 more source