Results 61 to 70 of about 442,790 (264)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Revista de Economia Contemporânea, 2018 RESUMO Este estudo estima a probabilidade de produtores rurais participarem de um programa de pagamentos por serviços ambientais (PSA) na bacia do rio Paraíba do Sul, Brasil, para atividades de conversão produtiva, conservação e regeneração florestal ...
Isaque Regis Ouverney +3 more
doaj +1 more source
Decisions under Risk and Uncertainty [PDF]
Risk in Contemporary Economy, 2021 Decision-making processes, like most economic processes, are influenced by a variety of factors, more or less known. The level of knowledge, but also the behavioral profile of the decision makers determines, to a large extent, their directions of action.
Sbughea Corina, Aldea Anamaria
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Cognitive Processes in Decisions Under Risk Are Not the Same As in Decisions Under Uncertainty
Frontiers in Neuroscience, 2012 We deal with risk versus uncertainty, a distinction that is of fundamental importance for cognitive neuroscience yet largely neglected. In a world of risk (small world), all alternatives, consequences, and probabilities are known.
Kirsten G Volz, Gerd eGigerenzer
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Editorial for the special issue: “Novel Solutions or Novel Approaches in Operational Research”
Business Systems Research, 2018 Background Determining the location, boundaries and areas of land properties accurately in the land cadastre is essential. The named data are provided using coordinates, acquired from field measurements.
Drobne Samo +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source