Results 101 to 110 of about 9,072,523 (253)

Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience): study protocol of a mental health, HIV self-testing and livelihoods randomised controlled trial for advancing HIV prevention outcomes among urban refugee youth in Kampala, Uganda

BMJ Open
Introduction Research with urban refugee youth in Uganda has documented co-occurring social (e.g., poverty) and health (e.g., depression) disparities associated with HIV vulnerabilities.
Daniel Kibuuka Musoke, Aidah Nakitende, Carmen H Logie, Moses Okumu, Peter Kyambadde, Robert Hakiza, Lauren Tailor, Frannie MacKenzie, Zerihun Admassu, Brenda Katisi   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Simulation model to assess the validity of the clinical portfolio diet score used in the PortfolioDiet.app for dietary self-tracking: a secondary analysis of a randomized controlled trial in hyperlipidemic adults

Frontiers in Nutrition
IntroductionThe Portfolio Diet combines cholesterol-lowering plant foods for the management of cardiovascular disease risk. However, the translation of this dietary approach into clinical practice necessitates a user-friendly method for patients to ...
Meaghan E. Kavanagh, Meaghan E. Kavanagh, Andrea J. Glenn, Andrea J. Glenn, Andrea J. Glenn, Laura Chiavaroli, Laura Chiavaroli, Laura Chiavaroli, Gloria A. Morgan, Robert G. Josse, Robert G. Josse, Robert G. Josse, Robert G. Josse, Robert G. Josse, Vasanti S. Malik, Vasanti S. Malik, Christopher P. F. Marinangeli, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper   +29 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

Frontiers in Veterinary Science
In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples ...
Shuang Li, Shuang Li, Shuang Li, Na Yu, Na Yu, Na Yu, Yaoxin Tang, Yaoxin Tang, Yaoxin Tang, Chunshuang Liu, Chunshuang Liu, Chunshuang Liu, Ying Zhang, Ying Zhang, Ying Zhang, Xiaojie Chen, Xiaojie Chen, Xiaojie Chen, Hao Wu, Xiubo Li, Xiubo Li, Xiubo Li, Yiming Liu, Yiming Liu, Yiming Liu   +24 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population representative studies with 141 million participants.

Background Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to
Alfonso Siani, NCD Risk Factor Collaboration (NCD-RisC), Paola Russo   +2 more
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