Results 101 to 110 of about 7,082,018 (299)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML

International Journal of Genomics, 2017
Acute myeloid leukemia (AML) is a haematological malignancy characterized by the excessive proliferation of immature myeloid cells coupled with impaired differentiation.
Mirazul Islam, Zahurin Mohamed, Yassen Assenov   +2 more
doaj   +1 more source

Headache disorders as risk factors for sleep disturbances in school aged children. [PDF]

, 2005
Several epidemiological studies have shown the presence of comorbidity between various types of sleep disorders and different headache subtypes. Migraine without aura is a sensitive risk factor for disorders of initiating and maintaining sleep (odds ...
CAROTENUTO, M, GALLI, FEDERICA, GUIDETTI, Vincenzo, PASCOTTO, A., RUJU, F, TAGLIENTE F., R   +5 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience): study protocol of a mental health, HIV self-testing and livelihoods randomised controlled trial for advancing HIV prevention outcomes among urban refugee youth in Kampala, Uganda

BMJ Open
Introduction Research with urban refugee youth in Uganda has documented co-occurring social (e.g., poverty) and health (e.g., depression) disparities associated with HIV vulnerabilities.
Daniel Kibuuka Musoke, Aidah Nakitende, Carmen H Logie, Moses Okumu, Peter Kyambadde, Robert Hakiza, Lauren Tailor, Frannie MacKenzie, Zerihun Admassu, Brenda Katisi   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Comparison of the NHANES dietary screener questionnaire to the Automated Self-Administered 24-Hour Recall for Children in the Healthy Communities Study

Nutrition Journal, 2018
Background A dietary screener questionnaire (DSQ) was used to assess dietary outcomes among children in the Healthy Communities Study (HCS), a study of the relationships between programs and policies to prevent child obesity and child diet, physical ...
Sridharshi Chintha Hewawitharana, Frances Elizabeth Thompson, Catherine M. Loria, Warren Strauss, Jyothi Nagaraja, Lorrene Ritchie, Karen Lucy Webb   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Simulation model to assess the validity of the clinical portfolio diet score used in the PortfolioDiet.app for dietary self-tracking: a secondary analysis of a randomized controlled trial in hyperlipidemic adults

Frontiers in Nutrition
IntroductionThe Portfolio Diet combines cholesterol-lowering plant foods for the management of cardiovascular disease risk. However, the translation of this dietary approach into clinical practice necessitates a user-friendly method for patients to ...
Meaghan E. Kavanagh, Meaghan E. Kavanagh, Andrea J. Glenn, Andrea J. Glenn, Andrea J. Glenn, Laura Chiavaroli, Laura Chiavaroli, Laura Chiavaroli, Gloria A. Morgan, Robert G. Josse, Robert G. Josse, Robert G. Josse, Robert G. Josse, Robert G. Josse, Vasanti S. Malik, Vasanti S. Malik, Christopher P. F. Marinangeli, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper   +29 more
doaj   +1 more source