Results 121 to 130 of about 24,883,480 (353)

Poor family relationships in adolescence as a risk factor of in-patient psychiatric care across the life course: A prospective cohort study [PDF]

, 2020
Susanne Alm, Sara Brolin Låftman, Fredrik Sivertsson, Hannes Bohman   +3 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Unique risk factors for unplanned preterm delivery in the uterus transplant recipient [PDF]

, 2023
Liza Johannesson, Giuliano Testa, Nicole Petrillo, Anthony R. Gregg   +3 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

Frontiers in Veterinary Science
In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples ...
Shuang Li, Shuang Li, Shuang Li, Na Yu, Na Yu, Na Yu, Yaoxin Tang, Yaoxin Tang, Yaoxin Tang, Chunshuang Liu, Chunshuang Liu, Chunshuang Liu, Ying Zhang, Ying Zhang, Ying Zhang, Xiaojie Chen, Xiaojie Chen, Xiaojie Chen, Hao Wu, Xiubo Li, Xiubo Li, Xiubo Li, Yiming Liu, Yiming Liu, Yiming Liu   +24 more
doaj   +1 more source

Factor Price Risk and the Diffusion of Conservation Technology: Evidence from the Water Industry [PDF]

The paper examines the influence of factor price risk on factor-use efficiency through the adoption of conservation technology. The effect of a mean-preserving increase in factor price risk on optimal input-use efficiency is shown to be conditional on ...
David Sunding, Georgina Moreno
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimizing GLP-1 therapies for obesity and diabetes management

Obesity Pillars
Background: Glucagon-like peptide-1 (GLP-1) therapies are highly effective for weight loss and metabolic improvement in obesity and type 2 diabetes management.
Jarvis C. Noronha, Luc F. Van Gaal, Ian J. Neeland, Angela Fitch, Andreas FH. Pfeiffer, Laura Chiavaroli, Cyril WC. Kendall, John L. Sievenpiper   +7 more
doaj   +1 more source

On the interaction between market and credit risk: a factor-augmented vector autoregressive (FAVAR) approach [PDF]

The aim of the paper is to understand the interaction between market and credit risk. Using a comprehensive set of Italian data, we apply a factor model to identify the common sources of risk driving fluctuations in the real and financial sectors.
Roberta Fiori, Simonetta Iannotti
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source