Results 91 to 100 of about 26,899,739 (354)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Risk Factors for Severe Hand-Foot-Mouth Disease in China: A Systematic Review and Meta-Analysis [PDF]

, 2021
Peiqing Li, Yuge Huang, Danping Zhu, Sida Yang, Dandan Hu   +4 more
openalex   +1 more source

Epidemiology and Risk Factors of Osteosarcoma

Cancer Investigation, 2020
Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender.
L. R. Sadykova, A. Ntekim, Musalwa Muyangwa-Semenova, Catrin Rutland, J. Jeyapalan, N. Blatt, A. Rizvanov   +6 more
semanticscholar   +1 more source

Factors Associated with Increased Risk of Overweight and Obesity in Children: An Evidence from Boyolali, Central Java [PDF]

, 2018
Background: Childhood obesity is a major public health challenge both in developed and developing countries. The prevalence of childhood obesity has increased over few years. It is caused by imbalance between calorie intake and calories utilized.
Dewi, Y. L. (Yulia ), Salimo, H. (Harsono ), Wijayanti, D. (Dwi )   +2 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Cohort Profile: The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC)

Journal of Epidemiology
The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC) was initiated in Shanghai to address the need for a comprehensive and longitudinal study on iodine nutrition and its effects on maternal and offspring health.
Zhuo Sun, Huiting Yu, YiXian Li, Wei Lu, Zhengyuan Wang, Qi Song, Shupeng Mai, Zehuan Shi, Liping Shen, Wenqing Ma, Xin Cui, Chen Xin, Jiajie Zang   +12 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Scientific Reports
Tau proteins as neurofibrillary tangles are one of the molecular hallmarks of Alzheimer’s disease (AD) and play a central role in tauopathies, a group of age-related neurodegenerative disorders.
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocca   +5 more
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association
Angelakopoulou, A, Berry, DJ, Casas, JP, Caulfield, M, Cooper, J, de Faire, U, Deanfield, J, Drenos, F, Fowkes, FG, Gigante, B, Hardy, R, Hingorani, AD, Humphries, SE, Hypponen, E, Ireland, H, Jefferis, BJ, Kivimaki, M, Kuh, D, Kumari, M, Lathrop, M, Laxton, RC, Leander, K, Maniatis, N, Marmot, M, Morris, RW, Motterle, A, Munroe, PB, Palmen, J, Power, C, Price, J, Samani, N, Shah, S, Shah, T, Simpson, IA, Smeeth, L, Sofat, R, Talmud, PJ, Thomson, A, Tzoulaki, I, Verzilli, C, Wallace, C, Whincup, PH, Whittaker, JC, Wong, A, Ye, S   +44 more
core   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source