Results 111 to 120 of about 12,589,259 (348)

Factors Influencing Physical Risk Taking in Rock Climbing

, 2006
This study was designed to investigate factors influencing physical risk taking in the sport of rock climbing. Specifically, the relationships between physical risk taking, sensation seeking, spheres of control, and desirability of control were examined.
Lew Hardy, Gould, Daniel R., Tim Woodman, Daniel R. Gould, Taylor, Marcus K., Hardy, Lew, Woodman, Tim, Marcus K. Taylor   +7 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Best-Arm Identification Using Extreme Value Theory Estimates of the CVaR

, 2022
We consider a risk-aware multi-armed bandit framework with the goal of avoiding catastrophic risk. Such a framework has multiple applications in financial risk management. We introduce a new conditional value-at-risk (CVaR) estimation procedure combining
Dylan Troop, Troop, Dylan, Yu, Jia Yuan, Frédéric Godin, Jia Yuan Yu, Godin, Frédéric   +5 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Identification of Nonlinear Time Lag Systems by Improved Genetic Algorithm [PDF]

, 1999
In this paper. a new identification method is proposed which can obtain a good accuracy of identification of nonlinear time lag system on the basis of combination of genetic algorithm and sequence method.
ASAKURA, Toshiyuki, GUO, Qingzhi
core  

A Systematic Literature Review of Cargo Loss Risks in Road Transportation: Impacts and Future Directions

Safety
This systematic literature review aims to identify and discuss specific cargo loss risks in road transportation. The research also examines their impacts, challenges, and mitigation strategies.
Praiya Panjee, Varunya Kaewchueaknang, Sataporn Amornsawadwatana   +2 more
doaj   +1 more source

Identification of common genetic risk variants for autism spectrum disorder

Nature Genetics, 2019
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children.
J. Grove, S. Ripke, T. Als, M. Mattheisen, R. Walters, H. Won, Jonatan Pallesen, E. Agerbo, O. Andreassen, R. Anney, Swapnil Awashti, R. Belliveau, F. Bettella, J. Buxbaum, J. Bybjerg-Grauholm, Marie Bækvad-Hansen, Felecia Cerrato, K. Chambert, J. Christensen, C. Churchhouse, Karin Dellenvall, D. Demontis, S. Rubeis, B. Devlin, S. Djurovic, Ashley L. Dumont, J. Goldstein, C. Hansen, M. Hauberg, M. Hollegaard, S. Hope, D. Howrigan, Hailiang Huang, C. Hultman, L. Klei, J. Maller, Joanna Martin, Alicia R. Martin, J. Moran, M. Nyegaard, T. Nærland, D. Palmer, A. Palotie, C. Pedersen, M. Pedersen, Timothy dPoterba, J. Poulsen, B. S. Pourcain, P. Qvist, K. Rehnström, A. Reichenberg, J. Reichert, E. Robinson, K. Roeder, P. Roussos, E. Saemundsen, S. Sandin, F. Satterstrom, G. D. Smith, H. Stefánsson, S. Steinberg, C. Stevens, P. Sullivan, P. Turley, G. Walters, Xinyi Xu, N. Wray, M. Trzaskowski, E. Byrne, A. Abdellaoui, M. Adams, Tracy M. Air, Till F. M. Andlauer, S. Bacanu, A. Beekman, T. Bigdeli, E. Binder, D. Blackwood, J. Bryois, H. Buttenschøn, N. Cai, E. Castelao, Toni‐Kim Clarke, J. Coleman, L. Colodro-Conde, B. Couvy-Duchesne, N. Craddock, Gregory E. Crawford, G. Davies, I. Deary, F. Degenhardt, E. Derks, N. Direk, C. Dolan, E. Dunn, T. Eley, V. Escott-Price, Farnush Farhadi Hassan Kiadeh, H. Finucane, A. Forstner, J. Frank, Héléna A. Gaspar, M. Gill, F. Goes, S. Gordon, L. Hall, T. Hansen, S. Herms, I. Hickie, P. Hoffmann, G. Homuth, Carsten Horn, J. Hottenga, M. Ising, R. Jansen, E. Jorgenson, J. Knowles, I. Kohane, J. Kraft, Warren W. Kretzschmar, J. Krogh, Z. Kutalik, Yihan Li, P. Lind, D. Macintyre, D. MacKinnon, Robert M. Maier, Wolfgang Maier, J. Marchini, H. Mbarek, Patrick J. McGrath, P. McGuffin, S. Medland, D. Mehta, C. Middeldorp, E. Mihailov, Y. Milaneschi, L. Milani, Francis M. Mondimore, G. Montgomery, S. Mostafavi, N. Mullins, M. Nauck, B. Ng, M. Nivard, D. Nyholt, P. O’Reilly, H. Oskarsson, M. Owen, J. Painter, Roseann E. Peterson, E. Pettersson, W. Peyrot, G. Pistis, D. Posthuma, J. Quiroz, John P. Rice, B. Riley, M. Rivera, S. Mirza, R. Schoevers, E. Schulte, Ling Shen, Jianxin Shi, S. Shyn, E. Sigurdsson, Grant C. B. Sinnamon, J. Smit, Daniel J. Smith, F. Streit, J. Strohmaier, K. Tansey, H. Teismann, A. Teumer, Wesley Thompson, P. Thomson, T. Thorgeirsson, M. Traylor, J. Treutlein, V. Trubetskoy, A. Uitterlinden, D. Umbricht, S. Auwera, A. M. Hemert, A. Viktorin, P. Visscher, Yunpeng Wang, B. Webb, S.M. Weinsheimer, J. Wellmann, G. Willemsen, S. Witt, Yang Wu, H. Xi, Jian Yang, Futao Zhang, V. Arolt, B. Baune, K. Berger, D. Boomsma, S. Cichon, U. Dannlowski, E. D. Geus, J. DePaulo, E. Domenici, K. Domschke, T. Esko, H. Grabe, S. Hamilton, C. Hayward, A. Heath, K. Kendler, S. Kloiber, G. Lewis, Qingqin S. Li, S. Lucae, P. Madden, P. Magnusson, N. G. Martin, A. McIntosh, A. Metspalu, B. Müller-Myhsok, M. Nöthen, M. O’Donovan, S. Paciga, N. Pedersen, B. Penninx, R. Perlis, D. Porteous, J. Potash, M. Preisig, M. Rietschel, C. Schaefer, T. Schulze, J. Smoller, H. Tiemeier, R. Uher, H. Völzke, Myrna M. Weissman, C. Lewis, D. Levinson, G. Breen, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, Bethann S. Hromatka, K. Huber, A. Kleinman, N. Litterman, M. McIntyre, J. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. V. Sazonova, J. Shelton, S. Shringarpure, J. Tung, V. Vacic, C. Wilson, K. Stefánsson, D. Geschwind, M. Nordentoft, D. Hougaard, T. Werge, O. Mors, P. Mortensen, B. Neale, M. Daly, A. Børglum   +275 more
semanticscholar   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach

, 2019
Neurodevelopmental disorders (NDDs) begin in the earliest months of life, but the clinical manifestations of many such disorders—including intellectual disability, autism spectrum disorder, attention‐deficit hyperactivity disorder, and fetal alcohol ...
Alvares, Gail, Jenny Downs, Leonard, Helen, Downs, Jenny, Helen Leonard, Amy Finlay‐Jones, Kandice Varcin, Bosco, Anthony, Anthony Bosco, Gail Alvares, Finlay‐Jones, Amy, Varcin, Kandice   +11 more
core   +1 more source