Results 41 to 50 of about 15,658,858 (315)

Narcotics information management system in South Korea: system development and innovation

BMC Health Services Research, 2023
Background As the misuse and abuse of medical narcotics are increasing in South Korea, an information system for the integrated information management of medical narcotic drugs across the nation is needed.
Sang-Yoon Kim, Nam-Wook Cho, Myung-Sik Yoo, Soon-Young Han, Jeong-Wyan Oh   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

ON ASSESSING THE MORBIDITY OF THE POPULATION ASSOCIATED WITH THE ATMOSPHERIC AIR QUALITY ON THE EXAMPLE OF A RUSSIAN CONSTITUENT ENTITY

Siberian Journal of Life Sciences and Agriculture, 2022
According to the World Health Organization (WHO), 24% of the global burden of diseases and 23% of all deaths associate with environmental factors. The presence of chemical impurities in the air can have an adverse effect on the health of the population ...
Nadezhda V. Nikiforova, Nina V. Zaitseva, Svetlana V. Kleyn   +2 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Why People Live in Flood-Prone Areas in Akuressa, Sri Lanka

International Journal of Disaster Risk Science, 2018
To investigate why people live in areas at high risk of floods, a qualitative case study was carried out in the areas around Akuressa, in southwest Sri Lanka.
Johan Askman, Olof Nilsson, Per Becker
doaj   +1 more source

Towards Sustainable Management of Urban Ecological Space: A Zoning Approach Hybridized by Ecosystem Service Value and Ecological Risk Assessment [PDF]

, 2022
Yuzhe Wu, Chenzhuo Gu, Yingnan Zhang
openalex   +1 more source

Machine Learning in Banking Risk Management: A Literature Review

Risks, 2019
There is an increasing influence of machine learning in business applications, with many solutions already implemented and many more being explored. Since the global financial crisis, risk management in banks has gained more prominence, and there has ...
M. Leo, Suneel Sharma, K. Maddulety
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evaluation of climate induced hazards risk for coastal Bangladesh: a participatory approach-based assessment

Geomatics, Natural Hazards & Risk, 2021
Bangladesh has been identified as one of the most susceptible countries to climate induced disasters. Geographical location of the country in the foothill of Himalayan system and in the mouth of north Bay of Bengal make it to experience frequent extreme ...
Md Faisal, Milton Kumar Saha, Md Abdus Sattar, A. K. M Abdul Ahad Biswas, Md Afjal Hossain   +4 more
doaj   +1 more source