Results 71 to 80 of about 4,631,625 (311)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Quantifying Elevation Changes Under Engineering Measures Using Multisource Remote Sensing and Interpretable Machine Learning: A Case Study of the Chinese Loess Plateau

Remote Sensing
Understanding the effectiveness of engineering measures in mitigating surface erosion is crucial for sustainable land management. However, studies explicitly quantifying the combined effects of large-scale engineering measures and environmental factors ...
Songhe Zhou, Qiuyue Zhu, Sijin Li
doaj   +1 more source

BIM-based digital platform and risk management system for mountain tunnel construction. [PDF]

Sci Rep, 2023
Liu N, Guo D, Song Z, Zhong S, Hu R.
europepmc   +1 more source

Risk management system

Шляхи підвищення ефективності будівництва в умовах формування ринкових відносин, 2018
The article deals with the risk management strategy of the Bank and observes the principle of break-even activity, aimed at ensuring the optimal balance between the profitability of individual business areas and the level of risk assumed by the Bank in carrying out certain operations.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Concurrent Decadal Trend Transitions of Sea Ice Concentration and Sea Surface pCO₂ in the Beaufort Sea

Remote Sensing
Interannual climate changes and increasing atmospheric CO2 (AtmCO2) have significantly altered sea surface partial pressure of CO2 (pCO2) in the Beaufort Sea (BS).
Shangbin Chi, Meibing Jin
doaj   +1 more source

Retracted: Applying Blockchain Technology in Network Public Opinion Risk Management System in Big Data Environment. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

A methodology for integrated risk management and proactive scheduling of construction projects. [PDF]

An integrated methodology is developed for planning construction projects under uncertainty. The methodology relies on a computer supported risk management system that allows to identify, analyze and quantify the major risk factors and derive the ...
Boone, A, Herroelen, Willy, Schatteman, Damien, Van de Vonder, Stijn   +3 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Long-term satellite records of water clarity suggest increasing human activity influence in an inland lake

International Journal of Digital Earth
Water clarity is a key indicator of trophic status and lake health, yet its long-term trends and driving factors remain underexplored due to limited historical data.
Jian Wang, Deyong Sun, Shengqiang Wang, Hailong Zhang, Yue Zhang, Miao He   +5 more
doaj   +1 more source