Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Assessment of Risks of Voltage Quality Decline in Load Nodes of Power Systems
The results of numerous studies show that the control of power grid modes is carried out mainly using a technical criterion. The economic criterion is taken into account through the use of complex and inaccurate models that do not accurately predict the ...
Pylyp Hovorov +4 more
doaj +1 more source
Numerical Modeling of Marine Circulation, Pollution Assessment and Optimal Ship Routes
Methods and technology have been developed to solve a wide range of problems in the dynamics of sea currents and to assess their “impact” on objects in the marine environment.
Vladimir Zalesny +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Risk management in supply chains in industrial enterprises: theoretical and methodological analysis
Modern companies operate in an environment of heightened uncertainty and rapid change, requiring them to adapt flexibly to shifting external conditions.
O. Koshkina
doaj +1 more source
Methods of Estimating Operative Risks in Trade
The article deals with Russian retail trade. Today it is very topical due to our economy digitalization and sanctions introduced by some foreign countries. The authors study methodological approaches to the analysis of operative risks in trade and search
G. P. Fomin +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Implicit and explicit risk perception, affect, and trust : an investigation of food "traffic lights" [PDF]
Obesity is a health problem in many developed countries and is a growing problem worldwide. In an effort to improve food choices the "traffic lights" nutritional labelling system has been developed.
Burns, Calvin +2 more
core +3 more sources

