Results 71 to 80 of about 5,669,348 (244)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Leveraging Artificial Intelligence for Real-Time Risk Detection in Ship Navigation

open access: yesApplied Sciences
The desire to improve the safety of navigation, especially in restricted and very busy areas like the straits, leads researchers to evaluate possible uses of Artificial Intelligence as an alternative to the traditional probabilistic methods.
Emmanuele Barberi   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Continual Invariant Risk Minimization [PDF]

open access: yes, 2023
Empirical risk minimization can lead to poor generalization behavior on unseen environments if the learned model does not capture invariant feature representations.
Niepert, Mathias   +2 more
core   +1 more source

Artificial intelligence: risks and their minimization practices

open access: yesОвощи России
Relevance. The study focuses on minimizing the risks associated with artificial intelligence (AI) application in vegetable farming, aligning with global trends such as Responsible AI and AgriTech Sustainability.Methods.
T. Yu. Shabanov, A. A. Kopchenov
doaj   +1 more source

Fiscal Risk Minimization Tools, Transfer Pricing Associated [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2020
Given the conditions of transparency amplification by introducing supplementary reports on the activity of sub holding companies, fiscal administrations grow to be more and more interested in the national budget income increase, therefore intensifying ...
Mihaela Paraschiva Luca   +2 more
doaj  

Three-Benchmarked Risk Minimization for Jump Diffusion Markets [PDF]

open access: yes
The paper discusses the problem of hedging not perfectly replicable contingent claims by using a benchmark, the numerraire portfolio, as reference unit.
Ke Du, Eckhard Platen
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

FEATURES OF TERRITORY BUDGET RISKS AND WAYS OF THEIR MINIMIZATION

open access: yesRussian Journal of Economics and Law, 2013
The article describes the prerequisites of budget risks occurrence, and consequences of their realization for the local budget parameters. The author defines budget risk and formulates the algorithm of carrying out managerial actions for risk ...
S. N. Yushkin
doaj  

Received on

open access: yes, 2008
. In this paper we present a novel method for selecting descriptor subsets by means of Support Vector Machines in classification and regression – the Incremental Regularized Risk Minimization (IRRM) algorithm. In contrast to many other wrapper methods it
Jörg K. Wegner   +3 more
core  

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