Results 51 to 60 of about 1,440,519 (266)

Automating risk of bias assessment for clinical trials [PDF]

Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, 2014
Systematic reviews, which summarize the entirety of the evidence pertaining to a specific clinical question, have become critical for evidence-based decision making in healthcare. But such reviews have become increasingly onerous to produce due to the exponentially expanding biomedical literature base.
Iain James Marshall, Joël Kuiper, Byron C. Wallace   +2 more
openaire   +7 more sources

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Technology-assisted risk of bias assessment in systematic reviews requires precise definitions of risk of bias [PDF]

Journal of Clinical Epidemiology, 2018
Technology-assisted risk of bias assessment in systematic reviews requires precise definitions of risk of ...
openaire   +2 more sources

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Efficacy and Safety of Vagus Nerve Stimulation for Hospitalized COVID-19 Patients: A Systematic Review and Methodological Evaluation of Randomized Controlled Trials

Medicina
Background and Objectives: Coronavirus disease 2019 (COVID-19) is characterized by excessive inflammatory responses, including the so-called cytokine storm, which contributes substantially to morbidity and mortality in hospitalized patients.
Adrian Balan, Giles Graham, Herban Sorin, Marius Marcu, Nini Gheorghe, Mara Gabriela, Andreea-Roxana Florescu, Alina-Mirela Popa, Ana Lascu, Cristian Ion Mot, Stefan Mihaicuta, Stefan Marian Frent   +11 more
doaj   +1 more source

Measuring risk aversion with lists: a new bias [PDF]

Theory and Decision, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Antoni Bosch-Domènech, Joaquim Silvestre   +1 more
openaire   +8 more sources

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Estimating the effect of COVID-19 on trial design characteristics: a registered report

Royal Society Open Science, 2023
There have been reports of poor-quality research during the COVID-19 pandemic. This registered report assessed design characteristics of registered clinical trials for COVID-19 compared to non-COVID-19 trials to empirically explore the design of clinical
James A. Smith, Nicholas DeVito, Hopin Lee, Catherine Tiplady, Roxanna E. Abhari, Christiana Kartsonaki   +5 more
doaj   +1 more source

The risk of bias from omitted research

BMJ, 2000
The rise of evidence based health care has highlighted the use of ineffective interventions, the risks of uncoordinated research, and the consequences of relying on studies published in prestigious journals while ignoring unpublished ones that have negative findings.1-5 Systematic reviews of the best evidence are now recognised as fundamental tools in ...
S, Garattini, A, Liberati
openaire   +3 more sources