Results 41 to 50 of about 7,559,776 (293)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.Ilaria Chiaradia, Madeline A. Lancasterwiley +1 more sourceApplication of Large-Scale Rotating Platforms in the Study of Complex Oceanic Dynamic Processes
Journal of Marine Science and EngineeringAs the core components of geophysical dynamic system, oceans and atmospheres are dominated by the Coriolis force, which governs complex dynamic phenomena such as internal waves, gravity currents, vortices, and others involving multi-scale spatiotemporal ...Xiaojie Lu, Guoqing Han, Yifan Lin, Qian Cao, Zhiwei You, Jingyuan Xue, Xinyuan Zhang, Changming Dong +7 moredoaj +1 more sourcePrediction of Genetic Risk for Hypertension [PDF]
Hypertension, 2003 Although genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for ...Hideo, Izawa, Yoshiji, Yamada, Taro, Okada, Masashi, Tanaka, Haruo, Hirayama, Mitsuhiro, Yokota +5 moreopenaire +2 more sourcesThe human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt +4 morewiley +1 more sourceC-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction [PDF]
, 2012 BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.Iso, Hiroyasu, Kiechl, S. (Stefan), Ridker, P.M., Danesh, J, Ingelsson, E., Fowkes, F. Gerry R., Caslake, M, Ford, I. (Ian), Pennells, L, Folsom, AR, Woodward, M., Thompson, S. G., Barr, E.L., Tybjærg-Hansen, Anne, Walker, M. (Mark), Rodriguez, B. (Beatriz), Kitamura, Akihiko, Lowe, Gordon D O, Howard, BV, Iso, H. (Hiroyasu), Gao, P, Shea, S, Whincup, PH, Jorgensen, T, Deeg, D.J.H. (Dorly), Ford, I, Gillum, R. F., Dekker, Jacqueline M, Walker, M, Cooper, J. A., Davey Smith, George, Barr, EL, Butterworth, Adam S., Woodward, M. (Mark), Lawlor, D.A. (Debbie), Hofman, A., Butterworth, AS, Folsom, A.R. (Aaron), Dekker, JM, Björkelund, C, Björkelund, C. (Cecilia), Barr, E., Nordestgaard, Børge G., Shea, Steven, Khaw, K-T. (Kay-Tee), White, I. R., Kiyohara, Y., Stehouwer, C.D.A., Packard, Chris J, Pennells, L. (Lisa), Gallacher, John, Tipping, R.W., Sattar, N, Gaziano, JM, Emerging Risk Factors Collaboration, Emerging Risk, Factors, Danesh, J., Bakker, Stephan J. L.; id_orcid, Onat, A., Wood, A., Pepys, M.B. (Mark), Dankner, R, Salomaa, Veikko, D'Agostino, R.B., Thompson, S.G., Salonen, JT, Kuller, L.H. (Lewis), Engström, Gunnar,, Bjorkelund, C., Giampaoli, S. (Simona), Ingelsson, Erik, Ridker, P. M., Benjamin, Emelia J, Salonen, Jukka T, Cremer, P, Gaziano, J.M., Salomaa, V, Rosengren, Annika,, Wood, AM, Ford, Ian, Benjamin, E., Nordestgaard, B.G., Salonen, J.T., Nissinen, A, et al., Fowkes, F Gerry R, Lowe, GDO, Howard, B.V. (Barbara), Dekker, J.M., Fowkes, FG, Cooper, J.A. (Jackie), Dagenais, G. R., D'Agostino, RB, Wennberg, P., Meade, Tom W, Benjamin, EJ, Meade, T. (Tom), Deeg, D., Dekker, J.M. (Jacqueline), Jorgensen, T. (Torben), Butterworth, Adam S, Dankner, R., Lawlor, Debbie A., Deeg, D.J.H., Di Angelantonio, E, Thompson, A. (Alexander), Stehouwer, C.D. (Coen), Wareham, N.J. (Nick), Jørgensen, T, Kiyohara, Yutaka, Bakker, Stephan JL, Folsom, A.R., Gudnason, V. (Vilmundur), Tosetto, Alberto, Wareham, N.J., Dagenais, G.R. (Gilles R), Caslake, M. (Muriel), Tipping, R. W., Davey-Smith, George, Barrett-Connor, Elizabeth, Benjamin, E.J., Kiyohara, Y. (Yutaka), Shaffer, Jonathan A., Meade, T.W., Gao, P., Barrett-Connor, E. (Elizabeth), Thompson, Simon G, Kromhout, D., Tipping, RW, Gaziano, J Michael, Bakker, SJL, D'Agostino, R. B., Brenner, H., Panagiotakos, D. B., Assmann, Gerd, Meade, Tom W., Tipping, Robert W, Shaffer, JA, Brunner, E. (Eric), Brunner, Eric, Barr, E.L.M., Westendorp, R. G., Lund University., Butterworth, A.S., Nissinen, A. (Aulikki), Ridker, PM, Khaw, K. T., Whincup, P.H., Koenig, W, Folsom, Aaron R, Benjamin, E. J., Shea, S., Gudnason, V, Bakker, SJ, Packard, C.J., Koenig, Wolfgang, Strandberg, T. E., Packard, CJ, Pepys, Mark B, Panagiotakos, D.B. (Demosthenes), Bakker, S., Wareham, N. J., Stehouwer, CD, Wareham, NJ, Kuller, Lewis H., Rosengren, A, Gaziano, J. M., Assmann, G. (Gerd), Wood, Angela M., Barr, Elizabeth LM, Thompson, Alexander, Gillum, R.F. (Richard), Salomaa, V. (Veikko), Dekker, Jacqueline M., Engström, G, Brenner, H, Psaty, B. M., Deeg, Dory, Panagiotakos, Demosthenes B., Psaty, B.M. (Bruce), Pepys, M. B., Bakker, S.J.L. (Stephan), Rosengren, Annika, Assmann, G, Brunner, E, Kiechl, S, Wareham, Nicholas J., Jorgensen, T., Kromhout, Daan, Kromhout, D, Thompson, A., Dagenais, GR, White, I., Howard, B. V., Fowkes, F.G.R., Hofman, Albert, Giampaoli, S, Wennberg, Patrik, Cooper, Jackie A, Dagenais, Gilles R, Wassertheil-Smoller, S., Wilhelmsen, L, Tosetto, A., Dankner, Rachel, Iso, H, Onat, A, Amouyel, Philippe, Ingelsson, E, Yliopisto, Oulun, Amouyel, P., Kitamura, A, Strandberg, Timo E., Nordestgaard, B. G., White, IR, Di Angelantonio, E., Meade, T. W., Folsom, A. R., Howard, Barbara V., Whincup, Peter H., Kiechl, Stefan, Psaty, Bruce M., Pepys, MB, Dagenais, Gilles R., Khaw, K., Meade, TW, Westendorp, Rudi G, Giampaoli, Simona, Gudnason, V., Stehouwer, CDA, Jørgensen, Torben, Sarwar, S. (Sheryar), Rosengren, A. (Annika), Wilhelmsen, L. (Lars), White, I.R. (Ian), Tosetto, A, Wennberg, P. (Patrik), Angelantonio, E. Di, Brenner, H. (Hermann), Sarwar, Nadeem, Whincup, P.H. (Peter), Salomaa, V., Cooper, Jackie A., Davey-Smith, G. (George), Lowe, G.D.O., Bakker, Stephan J. L., Hofman, Bert, Folsom, Aaron R., Pepys, M.B., Sarwar, N., Deeg, D, White, Ian R, Koenig, W., Fowkes, F. G. R., Shaffer, Jonathan A, Kitamura, A., Caslake, M., Lowe, G.D.O. (Gordon), Psaty, Bruce M, Panagiotakos, DB, Stehouwer, C. D. A., Pepys, Mark B., Whincup, Peter H, Lowe, G. D. O., Di Angelantonio, Emanuele, Sattar, Naveed, Tipping, Robert W., Stehouwer, Coen D. A., Kiyohara, Y, Kuller, L.H., Khaw, KT, Shea, S. (Steven), Wennberg, P, Shaffer, J.A. (Jonathan), Westendorp, R.G., Giampaoli, S., Rosengren, A., Kaptoge, S., Gillum, Richard F, Wareham, Nicholas J, Walker, Matthew, Assman, Gerd, Gallacher, J. (John), Barr, ELM, Wood, Angela M, Ridker, Paul M, Benjamin, E.J. (Emelia), Benjamin, Emelia J., Kaptoge, S, Salonen, Jukka T., Gao, P. (Pei), Bakker, Stephan S. L., Davey-Smith, G., Lawlor, DA, Clarke, Robert, Pennells, Lisa, Kuller, LH, Barr, Elizabeth L M, Pennells, L., Brunner, E., Kiechl, S., Butterworth, A.S. (Adam), D'Agostino, Ralph B, Lawlor, D.A., Rodriguez, B, Clarke, R., Dekker, J. M., Barr, E. L. M., Barr, Elizabeth L. M., Barrett-Connor, E, Koenig, W. (Wolfgang), Lowe, Gordon D. O., Stehouwer, Coen DA, Cremer, Peter, Nissinen, A., Wood, A.M., Nissinen, Aulikki, Cremer, P., Wassertheil-Smoller, S. (Sylvia), Westendorp, R.G.J. (Rudi), Strandberg, T.E., Barrett-Connor, E., Bjorkelund, Cecilia, Gillum, R.F., Clarke, R. (Robert), Nordestgaard, B.G. (Børge), Shaffer, J. A., Engstrom, Gunnar, Gudnason, Vilmundur, Lawlor, D. A., Stehouwer, Coen D A, Packard, C. J., Khaw, Kay-Tee, Wood, A. M., Kuller, L. H., Tosetto, A. (Alberto), Kauhanen, J, D'Agostino, Ralph B., Gaziano, J.M. (J. Michael), Kuller, Lewis H, Sattar, N. (Naveed), Kromhout, D. (Daan), Khaw, K.T., Nordestgaard, BG, Iso, H., Rodriguez, Beatriz, Kaptoge, Stephen, Assmann, G., Clarke, R, Cooper, J.A., Caslake, Muriel, Emerging Risk Factors, Hofman, A. (Albert), Davey-Smith, G, Bakker, S.J.L., Howard, B.V., Bakker, Stephan J L, Sattar, N., Angelantonio, E. (Emanuele) di, D'Agostino, Ralph B., Sr., Lawlor, Debbie A, Gallacher, J., Tipping, A. (Alex), Ford, I., Danesh, John, Kauhanen, J. (Jussi), Björkelund, Cecilia,, Whincup, P. H., Cushman, M., Cushman, M, Strandberg, TE, Butterworth, A. S., Bakker, S. J. L., Ingelsson, E. (Erik), Fowkes, FGR, Rodriguez, B., Cooper, JA, Wassertheil-Smoller, S, Panagiotakos, Demosthenes B, Nordestgaard, Børge G, Panagiotakos, D.B., Kauhanen, J., Nordestgaard, Borge G., Ridker, P.M. (Paul), Kauhanen, Jussi, D'Agostino, R.B. (Ralph), Gillum, RF, Thompson, A, Danesh, J. (John), Stehouwer, Coen D. A.; id_orcid, Danker, Rachel, Sarwar, N, Psaty, BM, Walker, M., Packard, C. (Chris), Onat, A. (Altan), Westendorp, RG, Butterworth, A., White, Ian R., Thompson, S.G. (Simon), Wilhelmsen, L., Woodward, Mark, Dankner, R. (Rachel), Howard, Barbara V, Cushman, Mary, Gillum, Richard F., Strandberg, Timo E, Psaty, B.M., Hofman, A, Strandberg, T.E. (Timo), Wood, A.M. (Angela), Amouyel, P. (Philippe), Westendorp, Rudi G., Woodward, M, Lawlor, Debbie H., Lowe, Gordon DO, Salonen, J. T., Onat, Altan, Wilhelmsen, Lars, Gallacher, J, Wassertheil-Smoller, Sylvia, Lowe, GD, Cushman, M. (Mary Ann), White, I.R., Kaptoge, S. (Stephen), Deeg, Dorly, Brenner, Hermann, Dagenais, G.R., Engstrom, G., Amouyel, P, Gaziano, J. Michael, Shaffer, J.A., Jorgensen, Torben, Thompson, SG, Wennberg, Patrik,, Ridker, Paul M., Packard, Chris J., Fowkes, F.G.R. (F. Gerald R.), Gao, Pei, Thompson, Simon G., Bladbjerg, Else-Marie; id_orcid, Jespersen, Jørgen; id_orcid +440 morecore +3 more sourcesDesign and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş +5 morewiley +1 more sourceReconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 morewiley +1 more source
